Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

By N. Joza, S. Susin, E. Daugas, W. Stanford, Sarah K. Cho, Carol Y. J. Li, Takehiko Sasaki, A. Elia, H. M. Cheng, L. Ravagnan and 10 more. Nature, 2001

1,437 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2204fb3c033c8f0bf2632ad4be30b9c14e709a39

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Citations in the corpus

Cell death by mitotic catastrophe: a molecular definition (2004, background): “However, it is now well established that apoptosis may occur in a caspase-independent manner (Susin et al., 1999, 2000; Joza et al., 2001), meaning that failure to prevent cell death by caspase inhibitors cannot be used as an argument to define this type of cell death as nonapoptotic.”
The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “…2001; Parrish et al., 2001); and the contentious flavoprotein AIF, which on the one hand has been implicated in chromatin condensation and large-scale DNA degradation (Joza et al., 2001; Yu et al., 2002), but on the other in protecting neurons from peroxide-mediated apoptosis (Klein et al., 2002).”
Caspase-independent cell death (2005, background): “But genetic experiments suggest that AIF may have an important role in caspase-independent cell death in mic”
AIF deficiency compromises oxidative phosphorylation (2004, methodology): “On the other hand, failure to detect structural AIF mutations may reflect embryonic lethality of any major AIF deficiency, pre- sumably resulting from a teratogenic apoptosis defect and/or from a respiratory dysfunction (Joza et al, 2001; Wang et al, 2002).”
The harlequin mouse mutation downregulates apoptosis-inducing factor (2002, background): “However, chimaeric mice could not be generated from these targeted cells, leaving the role of AIF in the adult mouse unknow”
Mitochondrial membrane permeabilization in cell death. (2007, background): “Mouse embryonic stem (ES) cells lacking AIF due to homologous recombination are resistant against cell death induced by serum deprivation (356) (for a review, see Ref.”
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “In addition, AIF is required for specific cell death pathways including lethal responses to excitotoxins such as glutamate and N-methyl-D-aspartate (NMDA), DNA-alkylating agents, hypoxia–ischemia, or growth factor deprivation [132].”