Mitochondrial control of cell death

By Guido Kroemer, John Calvin Reed. Nature Medicine, 2000

3,233 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4e43d3a11bc51c49cf2f59435ff12e32d09a6495

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. C. Brenner
4. P. Boya
5. P. Codogno
6. Craig B. Thompson
7. B. Thomson
8. Frank Madeo

Citations in the corpus

• Inhibition of Macroautophagy Triggers Apoptosis (2005, background): “6A and B), suggesting that, as in other paradigms of apoptosis (21, 22, 38), caspase activation occurred downstream of MMP.”
• Glutathione in Cancer Biology and Therapy (2006, neutral): “acid (γ -Glu-aa) transporter; (3) dipeptidases; (4) Cyst(e)ine transporters; (5) γ -Glu-cyclotransferase; (6) 5-oxoprolinase; (7) GCS; (8) GSHS; (9) GPx; (10) GR; (11) transhydrogenases; (12) GSTs.”
• Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “Cyt c and other mitochondrial polypeptides were found to be released from the mitochondrial intermembrane space in the mitochondrial pathway [84].”
• Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “The enzyme and protein required for the oxidative phosphorylation are encoded by the mitochondrial DNA [9,10].”
• Viruses and apoptosis (2001, background): “It has recently become evident that mitochondria play a pivotal role in both the life and death of the cell (Green & Reed 1998; Kroemer & Reed 2000).”
• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options (2009, background): “Any mutation in Mt DNA leads to impaired ATP generation and perturbed oxidative phosphorylation cascade that may further lock the neuronal function [33].”
• ROS stress in cancer cells and therapeutic implications. (2004, background): “Decrease in the mitochondrial membrane potential, impairment of the mitochondrial respiratory chain, and depletion of ATP are characteristic consequences of oxidative stress (Kroemer and Reed, 2000; Brown and Borutaite, 2002).”
• The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. (2016, background): “Apoptosis is an energy-dependent mode of cell death with typical DNA fragmentation but lack of an inflammatory response, and is initiated extrinsically through sarcolemmal receptors and intrinsically by release of cytochrome C from damaged mitochondria.(46,47) Opening of the mitochondrial permeabili”