Physiological roles of mitochondrial reactive oxygen species

By Laura A. Sena, Navdeep S. Chandel. Molecules and Cells, 2012

2,484 citations recorded by the source corpus.

Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively cause cellular damage and lack a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. Thus, mROS were originally envisioned as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that mROS are critical for healthy cell function. In this review, we discuss this evidence following some background on the generation and regulation of mROS.

Subfields: Genetics, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4e07e28da90932a483c8cf1a374ec89a8866aab5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Physiology

Citations in the corpus

Antioxidant responses and cellular adjustments to oxidative stress (2015, neutral): “This process is called retrograde response [239,240].”
The hallmarks of aging. (2013, background): “Indeed, parallel and separate to the work on the damaging effects of ROS, the field of intracellular signaling has accumulated solid evidence for the role of ROS in triggering proliferation and survival in response to physiological signals and stress conditions (Sena and Chandel, 2012).”
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases (2020, background): “Moreover, there are non-enzymatic reactions, like the mitochondrial respiratory chain which involves NADPH oxidase, XOR, uncoupled endothelial NOS, cytochrome P450 enzymes, lipoxygenase and COX (Sena and Chandel, 2012; Battelli et al., 2014a).”
The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “Some examples are the regulation of cytosolic stress kinases, modulation of hypoxic signalling, and activation of macroautophagy [143–145].”
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling (2013, neutral): “Recent studies have indicated that mROS are not categorically harmful and that low levels of ROS are important for healthy cell function (Sena and Chandel, 2012).”
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer (2017, background): “At low concentrations, ROS play a physiological role in the defence against pathogens, the mitogenic response and in different molecular pathways [248–250].”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Maintaining the appropriate balance of ROS is essential [51].”