Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

By M. Sharifi-Rad, N. V. Anil Kumar, P. Zucca, E. Varoni, L. Dini, E. Panzarini, J. Rajković, P. T. Tsouh Fokou, E. Azzini, I. Peluso and 13 more. Frontiers in Physiology, 2020

1,659 citations recorded by the source corpus.

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.

Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/588d4b6b8e19d721b19142e9c79455fab0466c44

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. Mohd Salim Reshi
  2. S. Pramodh
  3. Ahmad Alsulimani
  4. R. Rani
  5. S. Haque
  6. M. Alkhanani
  7. Syed Sanober Qadri
  8. Shahid Yousuf Ganie

Citations in the corpus