Biology of the p21-activated kinases.
By G. Bokoch. Annual Review of Biochemistry, 2003
1,139 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/4db3d297829f9bc250dd5e3d9705cd7dfda646e6
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In Molecular Biology
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In Oncology
Citations in the corpus
- p21-activated kinases in cancer (2006, background): “These activities include growth-factor and steroid-receptor signalling, energy homeostasis, and transcription and mitosi”
- Cdc42 - the centre of polarity (2004, background): “…the actin cytoskeleton One of the best-characterized targets of Cdc42 and Rac is the p65PAK family of serine/threonine kinases (reviewed by Bokoch, 2003). p65PAK associates with F-actin in membrane ruffles and lamellipodia at the leading edge of polarized migrating cells, such as…”
- The role of the Rho GTPases in neuronal development. (2005, background): “A total of six members (PAK1–6) have been identified, of which PAK1–3 have been most extensively studied (Jaffer and Chernoff 2002; Bokoch 2003).”
- Paxillin: adapting to change. (2004, background): “ulate actomyosin function (20) as well as stimulate the”
- PI3 Kinase signals BCR dependent mature B cell survival (2009, neutral): “When we used these alleles in our experimental in vivo system, they failed to rescue BCR B cells in the spleen, despite their ability to increase phospho-Erk levels and PAK1 binding activity, respectively, in splenic B cells (Figure S5; Bokoch, 2003).”
- Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (2008, neutral): “There are numerous downstream effectors of Pak1 that regulate actin dynamics (Bokoch, 2003).”
- Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. (2005, neutral): “PAK1 is a Cdc42regulated kinase, and while it tends to decrease myosin II activation (Bokoch, 2003), there is evidence that it regulates actin retrograde flow in epithelial cells (Wittmann et al.”