Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

By J. Wadia, R. Stan, S. Dowdy. Nature Medicine, 2004

1,676 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4d6a40f387840b19b5b6172e7fc375a9e5608ccf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. I. Kaplan
2. S. Dowdy
3. J. Wadia
4. Joseph C. Sun
5. Cherine Bechara
6. S. Sagan

In Molecular Biology

1. I. Kaplan
2. J. Wadia
3. S. Dowdy
4. K. Sokolov
5. R. Fischer
6. T. Miller
7. Joseph C. Sun
8. S. Reiner

In Physiology

1. I. Kaplan
2. S. Dowdy
3. J. Wadia

Citations in the corpus

• Nanomedicine: current status and future prospects (2005, background): “(131) have generated a fusogenic influenza”
• Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. (2004, background): “Using a Tat–Cre fusion protein, Dowdy and co-workers recently suggested that raft-mediated macropinocytosis plays a crucial role in Tat-mediated cellular uptake of proteins [18].”
• Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “The recombination can only take place upon exogenous Cre-protein delivery to the nucleus [55,56].”
• A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides (2007, background): “Moreover, for a Tat–Cre conjugate used at a concentration of less than 1 mM, both lipid-raft-mediated endocytosis and macropinocytosis were identified as mechanisms contributing to internalization (15).”
• Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting (2007, positive): “Fusogenic peptides that are based on the N-terminal sequences of the influenza virus haemagglutinin protein destabilize membranes in a pH sensitive manner and have been applied to enhance cytoplasmic delivery of DNA and protein”
• Cationic TAT peptide transduction domain enters cells by macropinocytosis. (2005, methodology): “Consistent with recent results [12], confocal microscopy of live COS-7 cells treated with TAT PTD for 1 h demonstrated the presence of the fluoresceinated TAT PTD peptide in endosomal vesicles (Fig.”
• Molecular imaging and darkfield microspectroscopy of live cells using gold plasmonic nanoparticles (2009, background): “For example, peptides [33,60] can be used to target nanoparticles against specific molecules In addition, aptamers [55,61–63], molecular specific probes comprised of oligonucleotide sequences, can also identify targets of interest that can be a specific molecule or a cell type, such as gliomas [61] ”
• Cell-Penetrating Peptides: From Basic Research to Clinics. (2017, background): “One approach that has shown promising results is based on the introduction into the peptide sequence of pH-sensitive domains that destabilize lipid membranes at the acidic pH of endosomes, thus facilitating the escape of CPPs from endocytic vesicles [84].”
• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “Recent reports have demonstrated that the uptake of the TAT peptide and its cargos occurs by macropinocytosis (Kaplan et al., 2005; Nakase et al., 2004; Wadia et al., 2004).”