A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides

By Falk Duchardt, M. Fotin‐Mleczek, H. Schwarz, R. Fischer, R. Brock. Traffic : the International Journal of Intracellular Transport, 2007

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Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics (2009, positive): “The first contacts between the CPPs and the cell surface take place through electrostatic binding with cell surface proteoglycans GlucosAminoGlycan (GAG) platform, follow by a remodelling of the actin network and a selective activation of the British Journal of Pharmacology (2009) 157 195–206 small ”
Subcellular targeting strategies for drug design and delivery (2010, background): “Emerging studies suggest that, although some peptides can traverse the membrane through lipid interactions, conjugates of CPPs are mainly internalized by endocytosi”
Cell-penetrating peptides: design, synthesis, and applications. (2014, background): “of RNA, DNA, and tubulin that are involved in endocytotic events and cell signaling.(88) There are known mammalian transmembrane syndecans, and the”
Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “demonstrated that macropinocytosis for R9 prevails at concentration less than 10 lM [130].”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Three endocytic pathways appear to account for this process: macropinocytosis, clathrin-mediated endocytosis, and caveolae/lipid-raft-mediated endocytosis (Duchardt et al., 2007).”