Cationic TAT peptide transduction domain enters cells by macropinocytosis.

By I. Kaplan, J. Wadia, S. Dowdy. Journal of Controlled Release, 2005

681 citations recorded by the source corpus.

Subfields: Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/5976e65f0b894158bfa57eb8752c39f1acd12ed9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Kissel
2. T. Miller
3. P. Gleeson
4. Cherine Bechara
5. J. P. Lim
6. S. Sagan

In Virology

1. P. Gleeson
2. J. P. Lim

Citations in the corpus

• Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “As for Tat peptide, inhibiting macropinocytosis also led to a decrease in the uptake, suggesting macropinocytosis as a route of entry [56,136].”
• Macropinocytosis: an endocytic pathway for internalising large gulps (2011, methodology): “Numerous arginine-rich cell-penetrating peptides such as octo-arginine and human immunodeficiency virus–trans-activator of transcription (TAT) peptides have been used as carriers to deliver peptides and proteins into cells via macropinocytosis”
• Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds (2013, background): “(2007) beta-Sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes.”
• Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives (2005, background): “Lately, macropinocytosis, a specialized form of endocytosis that is independent of caveloe, clathrin and dynamin, has been suggested to be one possible entry mechanism [149].”
• Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics (2009, neutral): “Although, macropinocytosis has been reported as the major route of internalization of cationic CPPs (Wadia et al., 2004; Kaplan et al., 2005), other endocytotic pathways including clathrin- and caveolin-dependent endocytosis (Richard et al.”
• Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (2006, background): “Recent reports have demonstrated that the uptake of the TAT peptide and its cargos occurs by macropinocytosis (Kaplan et al., 2005; Nakase et al., 2004; Wadia et al., 2004).”