Neurogenesis in the adult human hippocampus

By P. Eriksson, E. Perfilieva, T. Björk-Eriksson, Ann-Marie Alborn, C. Nordborg, D. Peterson, Fred H. Gage. 1998

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In Neuroscience

Citations in the corpus

Continual Lifelong Learning with Neural Networks: A Review (2018, background): “During neurogenesis, the hippocampus’ dentate gyrus uses new neural units to quickly assimilate and immediately recall new information (Altman, 1963; Eriksson et al., 1998).”
Lifelong Learning of Spatiotemporal Representations With Dual-Memory Recurrent Self-Organization (2018, background): “…creating new neurons and connections in the Gamma-GWR do not resemble biologically plausible mechanisms of neurogenesis and synaptogenesis (e.g., Eriksson et al., 1998; Ming and Song, 2011; Knoblauch, 2017), the GWR learning algorithm represents an efﬁcient computational model that…”
Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “Previous analyses of human AHN did not address the effects of aging, although studies have examined AHN in older populations (Eriksson et al., 1998).”
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “Labeled neuronal cells in the GCL in patients that received a low dose of BrdU 13 , could possibly be explained by processes not associated with cell division 27,28 (Extended Data Fig.”
FearNet: Brain-Inspired Model for Incremental Learning (2017, background): “This occurs in HC’s dentate gyrus (Altman, 1963; Eriksson et al., 1998).”
Neural plasticity across the lifespan (2016, background): “We now know that in at least some areas of the human brain, new neurons are born.(29) Progress in the creation and manipulation of neural stem cells, in combination with advances in molecular biology, may mean that developmental plasticity once thought to be confined to early development may in the ”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “The field of adult neurogenesis took off after the introduction of bromodeoxyuridine (BrdU), a nucleotide analog, as a lineage tracer (Kuhn et al., 1996), and demonstrations of life-long continuous neurogenesis in almost all mammals examined, including humans (Eriksson et al., 1998).”
Emergence of multimodal action representations from neural network self-organization (2017, methodology): “While the process of neural growth of the GWR algorithm does not resemble biologically plausible mechanisms of neurogenesis (e.g., Eriksson et al., 1998; Gould, 2007; Ming & Song, 2011), it is an efficient learning model exhibiting a computationally convenient trade-off between adaptation to…”
Dynamics of hippocampal neurogenesis in adult humans (2013, positive): “A seminal study by Eriksson et al., 1998, provided the only direct evidence to date for adult neurogenesis in humans, although it did not enable researchers to assess the number of new neurons generated or the dynamics of this process.”
The underlying anatomical correlates of long-term meditation: Larger hippocampal and frontal volumes of gray matter (2009, background): “In support of the latter assumption, the human hippocampus was demonstrated to retain its ability to generate neurons throughout life (Eriksson et al., 1998), where regular practice may improve the rate of adult neurogenesis and foster the preservation of newly generated neurons (Gage, 2002).”
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus (2001, background): “Adult hippocampal neurogenesis has been demonstrated in birds (Barnea and Nottebohm,1994), reptiles (Lopez-Garcia, 1993), rodents (Altman and Das, 1965), and primates, including humans (Gould et al., 1997; Eriksson et al., 1998).”
Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy (2006, background): “DGC neurogenesis persists in adult monkeys and humans, the latter even into the eighth decade of life.(39) Pathological findings in the syndrome of mTLE include dispersion of the DGC layer and the appearance of hilar ectopic granule-like neurons.”
A hypothesis about the role of adult neurogenesis in hippocampal function. (2004, background): “In the adult human brain, neurogenesis has been detected in the DG (9), but no evidence of adult-born neurons has yet been found in the OB (35).”
Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, background): “…to the traditional view that neurogenesis in the mammalian brain ceases during prenatal development, it is now well established that the hippocampus continues to produce neurons well into late adulthood in several species, including humans (Altman and Das, 1965; Eriksson et al., 1998; Gross, 2002).”
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus (2004, background): “…radial glia; neural stem cells; proto-map New neurons continue to be born in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus of adult mammals, including humans (Altman and Das, 1965; Kaplan and Bell, 1984; Cameron et al., 1993; Gould et al., 1997, 1999b; Eriksson et al., 1998).”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “Adult neurogenesis, the birth of neurons in the adult animal, has been observed in the dentate gyrus of mice (Kempermann et al., 1997b), rats (Cameron et al., 1993), macaques (Gould et al., 2001), and humans (Eriksson et al., 1998) and is regulated quite similarly across species.”
The stress system in the human brain in depression and neurodegeneration. (2005, background): “Both apoptosis and neurogenesis continue to occur in this subregion into adulthood in mammals, including humans (Eriksson et al., 1998).”