Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine

By P. Vezina, D. Lorrain, Gretchen M. Arnold, Jennifer D. Austin, N. Suto. Journal of Neuroscience, 2002

629 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/4a0629e250966514da594300ccbccdaa816b7e5b

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Citations in the corpus

‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, neutral): “, via decrease in dopamine receptors) [9,22,111,174].”
Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, background): “tion (Vezina, 2004).”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “…break-point (willingness to work harder and harder for reward) and conditioned instrumental reinforcement (willingness to work for a reward-related CS) (Deroche et al. 1999; Piazza et al. 1989; Shippenberg and Heidbreder 1995; Vanderschuren and Kalivas 2000; Vezina 2004; Vezina et al. 2002).”
A Neural Computational Model of Incentive Salience (2009, result): “Such dynamic enhancement of CS incentive salience is also consistent with other behavioral demonstrations of incentive motivation enhancement by pharmacological dopamine activation or by psychostimulant-induced neural sensitization [72,73,79,80], even in the absence of additional learning [81–83].”
Structural plasticity associated with exposure to drugs of abuse. (2004, positive): “One form of behavioral plasticity produced by the repeated intermittent administration of psychostimulant drugs, whether they are EA or SA, is behavioral sensitization (Robinson and Berridge, 2000; Vezina, 2004).”
The incentive sensitization theory of addiction: some current issues (2008, background): “Conversely, sensitizing treatments with experimenter-administered drugs are sufficient to produce increased motivation for drug reward ( Vezina 2004), incentive sensitization of cue wanting (Robinson & Berridge 2000; Di Ciano 2007), cognitive impairment (Schoenbaum & Shaham 2008) and stronger S–”
Neurocircuitry of Addiction (2009, background): “Vezina P (2004). Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs.”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “Given its context dependence and persistence, sensitization has been proposed as a central neural mechanism underlying addiction (Robinson & Berridge 1993, 2003; Kalivas 2004; Vezina 2004).”
Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits (2007, neutral): “Over the last few years, there has been a growing emphasis placed upon effort-related processes that are involved in drug reinforcement (Marinelli et al. 1998; Nadal et al. 2002; Vezina et al. 2002; Czachowski et al. 2002; Colby et al. 2003).”
The reinstatement model of drug relapse: history, methodology and major findings (2003, positive): “Fourth, in rats sensitized to amphetamine a priming injection of the drug potentiates both reinstatement responding and DA release (Vezina et al. 2002).”
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, background): “…to Pavlovian conditioned stimuli and conditioned reinforcers as well as in increased breaking points in PR drug administration schedules (Vezina 2004) as well as enhanced drug-seeking behaviour in priming- but not stress-induced reinstatement (for a critical review of these findings,…”