The basics of epithelial-mesenchymal transition.

By Raghu Kalluri, R. Weinberg. Journal of Clinical Investigation, 2009

5,284 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/49bc7cb0f67a8d86b55dc82dacb2cb398515f8c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. R. Weinberg
2. M. Nieto
3. Jing Yang
4. Thomas Brabletz
5. Zena Werb
6. J. P. Thiery
7. Raghu Kalluri
8. Youhua Liu

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. Raghu Kalluri
4. Jing Yang
5. Zena Werb
6. D. Hanahan
7. Thomas Brabletz
8. M. Egeblad

In Oncology

1. R. Weinberg
2. M. Nieto
3. D. Hanahan
4. Jing Yang
5. Raghu Kalluri
6. Zena Werb
7. M. Karin
8. Thomas Brabletz

Citations in the corpus

• Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “known as the epithelial-to-mesenchymal transition (EMT) and its counterpart, the mesenchymal-to-epithelial transition [139].”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Therefore, we hypothesized that the downregulation of IL6R expression by miR-34a may contribute to MET mediated by p53.”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Y. Shintani, M. A. Hollingsworth, M. J. Wheelock, K. R. Johnson, Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH2-terminal kinase 1 and up-regulating N-cadherin expression.”
• Immunity, Inflammation, and Cancer (2010, background): “The first step is represented by epithelial-mesenchymal transition, in which cancer cells acquire fibroblastoid characteristics that increase their motility and allow them to invade epithelial linings/basal membranes and reach efferent blood vessels or lymphatics (Kalluri and Weinberg, 2009).”
• Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. (2012, background): “Studies using cell culture and tumor xenograft models show that activation of EMT promotes carcinoma cells to dissociate from each other and metastasize to distant organs (Hay, 1995; Kalluri and Weinberg, 2009; Thiery, 2002, 2009).”
• The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer (2017, neutral): “Scoring for CD31 and Gata6 was done according to staining intensity, with no (0), low (1), medium (2) and high (3) expression.”
• TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis (2016, background): “Vimentin is a well-recognized marker for EMT, as is E-cadherin for epithelial cells (Kalluri and Weinberg 2009).”
• The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “However, the EMTs associated with organ fibrosis are not plastic: The disease progresses so that the organs are finally mainly composed of activated fibroblastic and fibrogenic cells that lead to organ failure.”
• Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells (2013, background): “CTC analysis of three patients whose cancer lacks the translocation was used to establish specificity: a prostate cancer patient (lane 1), an EGFR mutant lung cancer patient (lane 2), and a HER2-amplified lung cancer patient (lane 6). ienceTranslationalMedicine.org 3 April 2013 Vol 5 Issue 179 179ra”
• Cellular and molecular mechanisms of renal fibrosis (2011, background): “Epithelial–mesenchymal transition Another source of matrix-producing cells could be tubular epithelium that undergoes EMT, a cell phenotypic conversion process that occurs during embryonic development, tumor metastasis and organ fibrosis”