Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.

By Q. Lu, T. Sun, Zhimin Zhu, N. Ma, M. García, Charles D. Stiles, David H. Rowitch. Cell, 2002

1,059 citations recorded by the source corpus.

The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord. Olig1 has roles in development and maturation of oligodendrocytes, evident especially within the brain. Both Olig genes contribute to neural pattern formation. Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4991f21afcaa369f26583ff7f939e470317f819d

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Citations in the corpus

Specification of motoneurons from human embryonic stem cells (2005, background): “2, homeodomain proteins expressed in ventral neural progenitor”
Origin of Oligodendrocytes in the Subventricular Zone of the Adult Brain (2006, methodology): “Recent evidence in vivo indicates that neurons and some glial cells are closely related in development and originate from common progenitors in ways that do not fit classical models that separate the neuronal and glial lineages (Williams et al., 1991; Richardson et al., 2000; He et al., 2001; Lu et ”
Neuronal fate determinants of adult olfactory bulb neurogenesis (2005, background): “Indeed, the maintenance of Olig2 expression interferes with neuronal differentiation, as previously show”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, methodology): “Therefore, we examined the TF Olig2, a key determinant of oligodendrocyte fate in development (Lu et al., 2002; Rowitch, 2004) and adulthood (Hack et al.”
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma (2008, positive): “We next investigated expression of the bHLH protein Olig2, which marks multilineage progenitor populations of the forebrain and the spinal cord (Petryniak et al., 2007; Lu et al., 2002; Zhou and Anderson, 2002).”
Regulation of innate immune responses in the brain (2009, background): “In addition, OLIG1 and OLIG2 have a role in the association of neurons and oligodendrocytes during developmen”
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. (2008, background): “Disruption of Olig2 leads to an ablated formation of oligodendrocytes in the spinal cord and lack of NG2 cells (Lu et al., 2002; Lignon et al., 2006).”
Why does remyelination fail in multiple sclerosis? (2002, background): “cgi?l=116448">Olig1 (oligodendrocyte transcription factor 1) might also be involved in OPC differentiation, as the onset of the expression of proteins that are expressed by mature oligodendrocytes during development is delayed in its absenc”
The glial identity of neural stem cells (2003, positive): “, consistent with accumulating evidence for a common oligodendrocyte/neuron progenitor during developmen”
Developmental genetics of vertebrate glial–cell specification (2010, background): “Olig1/2 null mutant mice show a failure in the development of motor neurons and OPCs in the spinal cord, as well as of all oligodendrocytes in the brai”