Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis.

By T. Kuhlmann, V. Miron, Q. Cuo, C. Wegner, J. Antel, Wolfgang Brück. Brain : a journal of neurology, 2008

840 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/a501b44923ab7cef053c8e5a2c2f5813f1897430

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Robin J. M. Franklin
2. P. Carpentier
3. Chao Zhao
4. D. Rowitch
5. T. Palmer
6. Fred H. Gage
7. Hongjun Song
8. R. Duman

In Neurology

1. Robin J. M. Franklin
2. P. Carpentier
3. T. Palmer
4. Fred H. Gage
5. Hongjun Song
6. C. Iadecola

In Pathology and Forensic Medicine

1. Robin J. M. Franklin

Citations in the corpus

• Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “The finding of OLPs and premyelinating oligodendrocytes in chronic lesions of MS suggest that remyelination is most vulnerable during their differentiation rather than their recruitment (Wolswijk 1998; Chang et al. 2002; Kuhlmann et al. 2008).”
• Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, positive): “Recent in vivo evidence suggests this failure is due to a block in the differentiation of these cells rather than their survival or recruitment (Kuhlmann et al., 2008).”
• Rejuvenation of regeneration in the aging central nervous system (2012, neutral): “nated MS lesions, which contain oligodendrocyte lineage cells that fail to differentiate into myelinating oligodendrocytes (Kuhlmann et al., 2008).”