Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

By K. Berer, M. Mues, Michail Koutrolos, Z. A. Rasbi, M. Boziki, C. Johner, H. Wekerle, G. Krishnamoorthy. Nature, 2011

1,217 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/484eb747b2a2ad02422b3a7e831ee449a8f93e11

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In Biological Psychiatry

1. Yan Wang
2. L. Kasper
3. Y. Belkaid

In Immunology

1. Yan Wang
2. L. Kasper
3. Helen Y Wang
4. Changsheng Xing
5. Rong‐Fu Wang
6. Y. Belkaid
7. T. Hand
8. M. Kronenberg

In Molecular Biology

1. Yan Wang
2. L. Kasper
3. Sergio E. Baranzini
4. Martin Dichgans
5. James Versalovic
6. G. Llovera
7. P. Hemarajata
8. Stefan Roth

Citations in the corpus

• Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation (2013, background): “Investigations with a murine experimental autoimmune encephalomyelitis (EAE) model demonstrated the role of intestinal microbiota as a trigger for autoimmunity driven by myelin-specific CD4+ T cells [Berer et al. 2011].”
• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, neutral): “The microbial flora and its products have been shown to control T cell-dependent inflammation through several mechanisms including the conversion of precursors provided by the diet into immune regulatory metabolites 13–15 .”
• Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “…models of multiple sclerosis prevents the development of relapsing-remitting demyelination M A N U S C R I P T A C C E P TE D ACCEPTED MANUSCRIPT 6 (Berer et al., 2011) and oral ingestion of probiotics attenuates neuroinflammation (Toumi et al., 2014; Luo et al., 2014). permeability hosts a and an…”
• Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters (2015, background): “demonstrated that EAE-resistant germ-free mice develop EAE spontaneously without any manipulation with adjuvant or pertussis toxin after recolonization with indigenous bacteria or a strain of segmented filamentous bacteria [9,10].”
• The role of microbiome in central nervous system disorders (2013, positive): “rent with attenuated Th1, Th17 and B cell responses, which related to the hygiene hypothesis yet contradicted findings in human MS (Berer et al., 2011; Lee et al., 2011).”