Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
By Connie M. Drysdale, D. McGraw, Catharine B. Stack, J. Stephens, Richard S. Judson, K. Nandabalan, Kevin Arnold, G. Ruaño, S. Liggett. Proceedings of the National Academy of Sciences of the United States of America, 2000
1,012 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology, Social Psychology
View Paper: https://www.semanticscholar.org/paper/4821bd6f7f407c79403550f0658bd07c2473ba4b
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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Brian L. Browning
- Sharon R. Browning
- Magnus Ingelman-Sundberg
- Richard M. Myers
- N. Risch
- H. Tabor
- Richard Durbin
- Jeffrey B. Endelman
In Social Psychology
Citations in the corpus
- Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. (2003, result): “Our demonstration of the interaction between two DRD2 SNPs bolsters the case for studying SNP combinations at particular candidate genes as opposed to single SNPs, and is consistent with work indicating that interactions of multiple SNPs within a haplotype affect biological traits of the human beta-”
- A Research Agenda For DSM-V (2002, background): “1999), as well as those of interest in relation to other common medical problems with complex genetics, such as diabetes, asthma, and hypertension (Barroso et al. 1999; Drysdale et al. 2000; Pritchard et al. 2000; Roses 2000).”
- Pharmacogenomics and individualized drug therapy. (2006, background): “At least 13 distinct SNPs have so far been identified in ADBR2 (105).”
- International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences (2005, methodology): “This approach has produced more predictive data for the 2-adrenergic receptor gene (Drysdale et al., 2000).”
- Candidate-gene approaches for studying complex genetic traits: practical considerations (2002, background): “Recently, there has been increased attention on the effects of polymorphisms in transcriptional promoters and regions of DNA that regulate the expression of gene”
- Haplotype phasing: Existing methods and new developments (2011, methodology): “For example, Clark's algorithm was used to phase 13 tightly linked SNPs in the β2 adrenergic receptor ( ADRB2 ) gene and found that a haplotype pair was significantly associated with bronchodilator response to a β-agonist in asthmatics, whereas individual SNPs were no”
- Neuregulin 1 and susceptibility to schizophrenia. (2002, background): “Alternatively, the functional variant may include more than one polymorphic site, and a haplotype may be necessary to account for the susceptibility, as has been suggested for other complex diseases (Drysdale et al. 2000; Horikawa et al. 2000).”
- A new algorithm for haplotype‐based association analysis: the Stochastic‐EM algorithm (2004, background): “…characterize the role of a candidate gene in the etiology of a complex trait, full haplotypic information should be exploited instead of using only genotypic information (Drysdale et al. 2000; Hodge et al. 1999; Joosten et al. 2001; Klerkx et al. 2002; Soubrier et al. 2002; Tregouet et al. 2002).”