Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor.

By J. Duan, M. Wainwright, J. M. Comeron, N. Saitou, A. Sanders, Joel Gelernter, P. Gejman. Human Molecular Genetics, 2003

969 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ad6d62de4c874955a16df1dbf8963c53278f6a6

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In Molecular Biology

1. Chava Kimchi-Sarfaty
2. Nouf S. Al-Numair
3. David Goldman
4. Zuben E. Sauna
5. Andrew C. R. Martin

Citations in the corpus

• Understanding the contribution of synonymous mutations to human disease (2011, background): “For example, a synonymous mutation in dopamine receptor D2 ( DRD2 ) results in a less stable mRNA secondary structure, which correlates with increased mRNA degradation and a lower protein leve”
• Genetic basis for individual variations in pain perception and the development of a chronic pain condition. (2005, background): “Therefore, we hypothesized that haplotype-specific secondary structures of mRNA affect COMT mRNA stability and/or efficiency of protein translation (25).”
• The SAAP pipeline and database: tools to analyze the impact and predict the pathogenicity of mutations (2013, background): “In addition to changes to the protein structure, mutations can have effects on expression, RNA splicing and RNA folding and stability [28-30].”