Ghrelin stimulates gastric acid secretion and motility in rats.

By Y. Masuda, T. Tanaka, N. Inomata, N. Ohnuma, Shoichiro Tanaka, Z. Itoh, H. Hosoda, M. Kojima, K. Kangawa. Biochemical and Biophysical Research Communications - BBRC, 2000

913 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/48143165e7c4cb52a9d71b37436a265887d175db

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In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Nutrition and Dietetics

Citations in the corpus

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. (2004, background): “Further insight into the apparently complex mechanisms regulating ghrelin secretion is based on studies showing an increase of circulating ghrelin levels in rats after surgical interventions such as vagotomy and hypophysectomy (32, 228).”
Ghrelin: structure and function. (2005, background): “Ghrelin stimulates gastric motility (68, 149), which makes it a candidate for the treatment of postoperative gastric ileus.”
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. (2001, background): “When administered either peripherally or centrally to rodents, ghrelin rapidly increases food intake and body weight (3–6) in addition to stimulating gastric motility and acid secretion (6,7).”
Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “GHSR expression in the dorsal vagal complex is also likely involved in ghrelin’s actions on stimulating gastric acid secretion (Masuda et al., 2000; Date et al., 2001).”
The G protein-coupled receptor subset of the rat genome (2007, background): “It has been shown that the ghrelin peptide with its receptor regulates gastrointestinal motility in rodents and the expression of GHSR in the human gastrointestinal tract indicates that ghrelin plays a role in gastrointestinal motility in humans as well [57-59].”
Ghrelin enhances appetite and increases food intake in humans. (2001, background): “Ghrelin is a gastric hormone and has been reported to stimulate gastric motility in rodents (7).”