Tumor angiogenesis: molecular pathways and therapeutic targets

By Sara M Weis, D. Cheresh. Nature Medicine, 2011

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Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis (2013, background): “Exosomal Angiogenic miRNAs from Cancer Cells Regulate Angiogenesis in Endothelial Cells—It is well known that angiogenic miRNAs regulate multiple endothelial cell functions and that nSMase2 is essential for miRNA secretion from cells (10, 20, 21).”
A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging (2018, neutral): “While vasculature is essential for tumor growth and survival by providing nutrients, and is accordingly a therapeutic target (Weis and Cheresh, 2011), it is also associated with increased immune infiltration into the tumor.”
Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. (2013, background): “39 Although antiangiogenesis therapy does not guarantee complete tumor regression, it is considered a promising antitumor therapy.(37,38) Taken together, our results suggest that NVDox exhibit Figure 6.”
Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “Additionally, MSCs have pro-angiogenic functions in the context of tumor development [230].”