4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.

By K. Uchida. Progress in lipid research, 2003

1,132 citations recorded by the source corpus.

Subfields: Biochemistry, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/47a2a85dcdd9c24ccbaf83bf8a567774981b4604

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Barry Halliwell
2. M. Whiteman
3. E. Kurutaş
4. A. Nègre-Salvayre
5. G. Barrera
6. Christelle Coatrieux
7. R. Salvayre
8. C. Ingueneau

In Organic Chemistry

1. M. Whiteman
2. E. Kurutaş
3. Barry Halliwell
4. G. Barrera

Citations in the corpus

• Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases (2019, background): “For example, peroxidation of omega-6 polyunsaturated fatty acid (such as arachidonic acid and linoleic acid) leads to the production of 4-hydroxynonenal (HNE), which is one of the main reactive aldehydes produced by oxidative stress [1].”
• Chronic inflammation and oxidative stress in human carcinogenesis (2007, background): “These molecules, at very low and nontoxic concentrations, act as signaling transductors of ROI-mediated metabolic reactions, and therefore, they modulate several cell functions including gene expression and cell proliferation.(66) In high concen-”
• Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors (2008, background): “reactivity, followed by His and Lys (Petersen and Doorn, 2004), but Cys–HNE adducts could be less stable than His– HNE adducts (Uchida, 2003).”
• Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “Indeed, immunochemical assays for protein-bound British Journal of Pharmacology vol 142 (2) aldehydes such as acrolein and 4-HNE are widely used (Uchida, 1999; 2003).”
• Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “in a Stem Cell Niche of Drosophila”
• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “Among the products of lipid peroxidation, 4-hydroxynonenal (HNE), is the most intensively studied [13, 14] since it is a highly electrophilic molecule that easily reacts with low-molecular-weight compounds, such as glutathione, with proteins and, at higher concentration, with DNA [15, 16].”
• Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, neutral): “We therefore examined the effects on TRPA1 of three major lipids produced during episodes of oxidative stress (Uchida, 2003): 4-HNE, 4-HHE, and 4-”
• The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “Moreover, lipid peroxidation may contribute to and amplify cellular damage resulting from generation of oxidized products, some of which are chemically reactive and covalently modify critical macromolecules [26].”