Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases
By Ankita Nandi, Liang-Jun Yan, C. Jana, N. Das. Oxidative Medicine and Cellular Longevity, 2019
1,008 citations recorded by the source corpus.
Reactive species produced in the cell during normal cellular metabolism can chemically react with cellular biomolecules such as nucleic acids, proteins, and lipids, thereby causing their oxidative modifications leading to alterations in their compositions and potential damage to their cellular activities. Fortunately, cells have evolved several antioxidant defense mechanisms (as metabolites, vitamins, and enzymes) to neutralize or mitigate the harmful effect of reactive species and/or their byproducts. Any perturbation in the balance in the level of antioxidants and the reactive species results in a physiological condition called “oxidative stress.” A catalase is one of the crucial antioxidant enzymes that mitigates oxidative stress to a considerable extent by destroying cellular hydrogen peroxide to produce water and oxygen. Deficiency or malfunction of catalase is postulated to be related to the pathogenesis of many age-associated degenerative diseases like diabetes mellitus, hypertension, anemia, vitiligo, Alzheimer's disease, Parkinson's disease, bipolar disorder, cancer, and schizophrenia. Therefore, efforts are being undertaken in many laboratories to explore its use as a potential drug for the treatment of such diseases. This paper describes the direct and indirect involvement of deficiency and/or modification of catalase in the pathogenesis of some important diseases such as diabetes mellitus, Alzheimer's disease, Parkinson's disease, vitiligo, and acatalasemia. Details on the efforts exploring the potential treatment of these diseases using a catalase as a protein therapeutic agent have also been described.
Subfields: Electrical and Electronic Engineering, Mechanics of Materials, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/e679340e1fb351fa52f36c86351d1cf2af450f7b
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Citations in the corpus
- Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “The CAT gene is found on chromosome 11 and regulates the synthesis of functional catalase, which consists of four identical porphyrin heme groups (Nandi et al. 2019).”
- Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases (2023, background): “Catalase is reported to play a dual role (Nandi et al., 2019).”