Chronic inflammation and oxidative stress in human carcinogenesis

By A. Federico, F. Morgillo, C. Tuccillo, Fortunato Ciardiello, C. Loguercio. International Journal of Cancer, 2007

987 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/a1612dc0567e9893cc12e4bf447d1f1b2c320a8b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Subash C. Gupta
2. Bharat B. Aggarwal
3. Wenyi Wei
4. Yu Chen
5. Lei Chen
6. Longqin Hu
7. T. Meng
8. M. Chaturvedi

In Pharmacology

1. Subash C. Gupta
2. Bharat B. Aggarwal

Citations in the corpus

• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, neutral): “and hydroxyl radicals [43–48].”
• Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “ROS can also recruit other inflammatory cells leading to additional ROS production and amplify the damage [32].”
• Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action (2022, background): “ROSinduced DNA damage results in induction/replication errors, transcriptional arrest, and/or genomic instability allied with carcinogenesis (Federico et al., 2007; Khansari et al., 2009).”
• Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents (2012, background): “174 Some naturally occurring coumarin derivatives, such as 4-methyl daphnetin (9),175 imperatorin (10),176 auraptene (11),176 and poncimarin (12),177 are reported to have ARE-mediated enzyme induction activities via Keap1-Nrf2-ARE pathway.”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “period of time may lead to carcinogenesis [70].”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, positive): “According to Dvorak’s 1986 comment, malignancies are regarded as “wounds that do not heal”.(223,224) As an important risk factor for malignancy, chronic immune activation and inflammation persistently promote TME formation by providing inflammatory mediators such as TNF-α, IL1β, IL-6 and TGF-β and u”
• Oxidative stress, aging, and diseases (2018, background): “damage other chemical or structural components in target cells or recruit other inflammatory cells leading to additional RONS production that amplifies the damage.(63) In particular, RONS and inflammatory cytokines, such as TNFα, activate the transcription factor NFκB, which induces the expression o”
• Role of Antioxidants and Natural Products in Inflammation (2016, background): “This inflammatory/oxidative environment triggers an unhealthy circle, which can harm healthy stromal cells and neighboring epithelial cells, which after a long period of time may trigger carcinogenesis [33, 36].”
• NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Consequently, chronic inflammation has been strongly associated with carcinogenesis [36–39].”