Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.

By R. Müller, K. Mäder, S. Gohla. European journal of pharmaceutics and biopharmaceutics, 2000

3,522 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/4793e811015c1c1374992f156d291f9ac977be47

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Citations in the corpus

Nanostructured lipid carriers: Promising drug delivery systems for future clinics. (2016, background): “Gasco (Italy) started to investigate the potential of a new nanoparticle-based formulation: the so-called solid lipid nanoparticles (SLNs).(1,2) Their formulation was based on lipids and presented, among others, the advantage of avoiding an organic solvent during the preparation method, contrary to ”
Nanocarriers for drug delivery applications (2018, background): “2009; Muller 2000).”
Biomedical applications of collagen. (2001, methodology): “Nanoparticles/nanospheres A property, in which the crystallites in the gel aggregates appear as multiple chain segments in the collagen-fold configuration, has been used to prepare aggregates as colloidal drug delivery carriers (Muller et al., 2000).”
Drug delivery and nanoparticles: Applications and hazards (2008, background): “The insert shows the application of the system with Rhodamine B encapsulated beads that is released after heating up to 45 o C.”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “Solid lipid nanoparticles (SLNs, which possess a solid core) or nanostructured lipid carriers (NLCs, which possess a liquid core) may be produced by highpressure homogenization (Müller et al., 2000; Mehnert and Mader, 2001; Hu et al., 2004c; Puri et al., 2009; Bunjes, 2010).”
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors (2017, background): “Organic nanocarriers Solid lipid nanoparticles (SLNs) SLNs, developed in early 1990s, are nanosized colloidal drug carriers in the size range of 50–1,000 nm.(7) SLNs are prepared by dispersing melted solid lipid(s) in water, whereas emulsifier(s) are used to stabilize the dispersion.”
Food-Grade Nanoemulsions: Formulation, Fabrication, Properties, Performance, Biological Fate, and Potential Toxicity (2011, background): “, tail group characteristics), and droplet size (Muller et al., 2000; Walstra, 2003; Muller and Keck, 2004).”
Development of nanoparticles for antimicrobial drug delivery. (2010, background): “SLNs are ideal for topical application as their occlusive property can induce film formation and prolong residence time on the stratum corneum [51, 52].”
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives (2007, methodology): “Drug incorporation models and types of SLN Factors affecting loading capacity of a drug in lipid are (Müller et al 2000): – solubility of drug in lipid melt, – miscibility of drug melt and lipid melt, – chemical and physical structure of solid matrix lipid, – polymorphic state of lipid material.”