Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives

By M. Üner, G. Yener. International Journal of Nanomedicine, 2007

606 citations recorded by the source corpus.

Solid lipid nanoparticles (SLN) have been reported to be an alternative system to emulsions, liposomes, microparticles and their polymeric counterparts for various application routes since the early 1990s due to their advantages. Various research groups have also increasingly focused on improving their stability in body fluids after administration by coating of particles with hydrophilic molecules such as poly(ethylene)glycol (PEG) derivatives. Altering surface characteristics by coating SLN with hydrophilic molecules improves plasma stability and biodistribution, and subsequent bioavailability of drugs entrapped. Their storage stability is also increased. This paper basicly reviews types of SLN, principles of drug loading and models of drug incorporation. The influence of PEG coating on particle size and surface characteristics is discussed followed by alteration in pharmacokinetics and bioavailability of drugs in order to target the site of action via SLN. The future direction of research and clinical implications of SLN is also considered.

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Citations in the corpus

Nanoparticles as drug delivery systems (2012, background): “Three types of NLC have been introduced: imperfect type NLC (general imperfections in the matrix nanostructure form free spaces for the accommodation of the guest molecules), multiple type NLC (drugs are solved in oils and protected from degradation by the surrounding solid lipid) and amorphous type”
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, background): “[79] Üner M, Yener G.”
Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “The lipid component may be triglycerides, fatty acids, waxes, steroids, and PEGylated lipids [80].”
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors (2017, background): “Lipids that are solid at room temperature are used in SLNs instead of liquid lipids (oils) used in nanoemulsions.(9) SLNs as nanocarriers offer a number of advantages over their colloidal counterparts, including nanoemulsions, liposomes and polymeric nanoparticles (PNPs).”
Nanocarriers for drug delivery applications (2018, background): “The solid form of lipids at room temperature like free fatty alcohol or acids; steroids or waxes; mono, di, or triglycerides are commonly used for the preparation of solid lipid nanocarriers (Üner and Yener 2007).”
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application. (2015, methodology): “These are including solid solution model, core-shell model (drugenriched Shell) and core-shell model (drug-enriched core) which is shown in Figure 2.(25,31,32)”