CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

By O. Gaide, B. Favier, D. Legler, David Bonnet, B. Brissoni, S. Valitutti, C. Bron, J. Tschopp, M. Thome. Nature Immunology, 2002

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CD28-mediated co-stimulation: a quantitative support for TCR signalling (2003, background): “CARMA1, similar to other MAGUK-type proteins, participates in sub-micron clustering of signalling complexes and accumulates in GEMs within 10–20 minutes after TCR triggerin”
The SYK tyrosine kinase: a crucial player in diverse biological functions (2010, background): “Constitutive kinase activation of the TEL–Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).”
Phosphorylation of the CARMA1 Linker Controls NF-κB Activation (2005, background): “Overexpression of CARMA1 enhances PMA- and Bcl10-dependent NF-kB activation that is blocked by expression of CARMA1 lacking the Bcl10-interacting CARD domain (Bertin et al., 2001; Gaide et al., 2002; McAllister-Lucas et al., 2001), implying that CARMA1 acts upstream of Bcl10.”
NF-κB and the immune response (2006, background): “The MAGUK family protein CARMA1 is required for activation of NF-kB in T cells following TCR ligation, but its loss has no effect on the development of thymocyte (Gaide et al., 2002; Egawa et al., 2003; Hara et al., 2003).”