Structural basis of caspase-7 inhibition by XIAP.

By J. Chai, E. Shiozaki, S. Srinivasula, Qi Wu, P. Dataa, E. Alnemri, Yigong Shi. Cell, 2001

606 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46dfb45a5dc5376c63015254c5c3c295d0811f8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. G. Salvesen
2. Yigong Shi
3. Simone Fulda
4. S. Riedl
5. X. Wang
6. C. Duckett
7. Peter Vandenabeele

In Molecular Biology

1. G. Salvesen
2. Simone Fulda
3. Yigong Shi
4. D. Vučić
5. S. Riedl
6. X. Wang
7. F. Scott
8. C. Duckett

Citations in the corpus

• Toxic proteins released from mitochondria in cell death (2004, background): “The mechanism by which Smac/DIABLO binds to the BIR2 domain of XIAP is unclear, although it requires the IBM and dimeric Smac/DIABLO (Wu et al., 2000; Chai et al., 2001).”
• Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “Inhibition of caspase 3 and caspase 7 involves the interaction of the linker region between the BIR1 and BIR2 domains of XIAP with the substrate-binding site of the activated caspas”
• IAP proteins: blocking the road to death's door (2002, background): “So, this important inhibitory domain in XIAP binds with high affinity to a surface that is conserved between caspase-3 and caspase-7, but XIAP is not a pseudosubstrate and functions solely to mask the active site in the caspas”
• Mechanisms of caspase activation and inhibition during apoptosis. (2002, background): “In support of this hypothesis, the linker peptide fused to glutathione S-transferase (GST) was able to ever, that an equivalent of p35 in mammals has not been identified.inhibit caspase-3 and -7 (Chai et al., 2001b; Huang et al., 2001).”
• The expanding role of mitochondria in apoptosis. (2001, background): “The linker sequence immediately preceding the BIR2 domain is involved in XIAP-mediated binding and inhibition of caspase-3 and caspase-7 (Sun et al. 1999; Chai et al. 2001; Huang 2001; Riedl et al. 2001).”
• Mechanism of XIAP-mediated inhibition of caspase-9. (2003, methodology): “However, careful evaluation scribed (Chai et al., 2001a, 2001b).”
• Cellular mechanisms controlling caspase activation and function. (2013, background): “XIAP can inhibit caspase-3 and caspase-7 by binding to the active site, and caspase-9 by preventing or reversing dimerization (Deveraux et al. 1997; Chai et al. 2001; Riedl et al. 2001; Srinivasula et al. 2001; Shiozaki et al. 2003).”