IAP proteins: blocking the road to death's door

By G. Salvesen, C. Duckett. Nature reviews. Molecular cell biology, 2002

1,878 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37eaa4d6440b014eff358aeee58f3772e77e8934

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Altieri
2. H. Beere
3. P. Johnston
4. G. van Loo
5. Scott W. Lowe
6. G. Salvesen
7. S. Riedl
8. M. Soengas

In Molecular Biology

1. G. Salvesen
2. Yigong Shi
3. S. Riedl
4. D. Altieri
5. F. Scott
6. Scott W. Lowe
7. H. Beere
8. M. Soengas

Citations in the corpus

• Mechanism of XIAP-mediated inhibition of caspase-9. (2003, background): “…apoptosis (IAP) family of proteins sup-370 Lancaster Avenue Haverford College presses apoptosis by inhibiting the enzymatic activity of both the initiator and the effector caspases (DeverauxHaverford, Pennsylvania 19041 3 Kimmel Cancer Center and Reed, 1999; Salvesen and Duckett, 2002; Shi, 2002b).”
• MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “…mitochondria release factors, including cytochrome c and SMAC/Diablo, that act by triggering the formation of the apoptosome (comprising cytochrome c, APAF-1, the initiator caspase 9 and dATP/ATP) and by inhibiting apoptosis inhibitors of the IAP family (Salvesen and Duckett, 2002), respectively.”
• The integrated stress response (2016, neutral): “This reduction in XIAP levels removes the brake on caspases and permits their activation with ensuing apoptosis [204,205].”
• Get a ligand, get a life: integrins, signaling and cell survival (2002, background): “…some of the heat shock proteins, IAPs bind to and inactivate executioner caspases but also serve other functions in the cell, including the regulation of cell division and cytokinesis, as well as signaling from TGFβ receptors to SMAD, NFkB and JNK pathways (reviewed in Salvesen and Duckett, 2002).”
• `The stress of dying': the role of heat shock proteins in the regulation of apoptosis (2004, background): “However, the apparent ability of Hsps to suppress caspase activity is reminiscent of the activity of the inhibitor of apoptosis proteins (IAPs), which can also inhibit the activity of proteolytically active caspases by binding to them (Salvesen and Duckett, 2002).”
• Molecular mechanisms of drug resistance (2005, background): “Another important level at which apoptosis is regulated is through inhibition of caspase activity by members of the IAP (inhibitors of apoptosis) family, which include c-IAP1, c-IAP2, X-IAP, and survivin [198].”
• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. (2006, background): “Most mouse models for liver cancer are based on germline transgenic approaches that direct expression of an oncogene to the liver using a tissue-specific promoter (Sandgren et al., 1989; Murakami et al., 1993).”
• Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “Negative regulation of caspases function is achieved by IAP proteins family whose principal members in humans are NAIP (BIRC1), cIAP1 (BIRC2), cIAP2 (BIRC3), X-linked IAP (XIAP, BIRC4), Survivin (BIRC5), Apollon (BRUCE, BIRC6), Livin/ML-IAP (BIRC7), and IAP-like protein 2 (ILP2 – BIRC8) [42].”
• Apoptosis and melanoma chemoresistance (2003, background): “Those studies lead to the identification of two groups of apoptotic ‘brakes’: IAPs and FLIPs (FLICE inhibitory proteins) later found overexpressed in multiple tumor types (Tschopp et al., 1998; Salvesen and Duckett, 2002).”