Suppressors of cytokine signalling (SOCS) in the immune system

By Warren S. Alexander. Nature reviews. Immunology, 2002

712 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/46b0d95c6e50a8a7da6ab5ab5aa4872c8b76a4b6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Gale
2. A. Yoshimura
3. M. Febbraio
4. D. Harrison
5. J. Rawlings
6. K. Rosler
7. Eileen M. Foy
8. Bin Liu

In Oncology

1. M. Gale
2. A. Yoshimura
3. D. Harrison
4. J. Rawlings
5. K. Rosler
6. Toshikatsu Hanada
7. Bin Liu
8. K. Shuai

Citations in the corpus

• Negative regulation of Toll-like receptor-mediated immune responses (2005, background): “Eight members in the SOCS family are known to be important in suppressing cytokine signallin”
• Regulation of JAK–STAT signalling in the immune system (2003, background): “cgi?l=9021">SOCS3 and CIS have been well studied in the regulation of JAK–STAT signallin”
• Muscle as an endocrine organ: focus on muscle-derived interleukin-6. (2008, background): “In addition, in immune cells, the COOH-terminal SOCS box is known to recruit ubiquitin-transferases to lead to degradation of JAK/STAT signaling proteins (10), and it has recently been shown that deletion of the SOCS box abrogates proteosomal degradation (225).”
• SOCS3 negatively regulates IL-6 signaling in vivo (2003, background): “The SOCS family comprises eight proteins (SOCS1–SOCS7 and CIS) containing a central SH2 domain and a carboxy-terminal SOCS box that act, at least in part, by targeting the signaling proteins to which they bind for polyubiquitination and proteosomal degradatio”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “SOCS protein family are eight members, including SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7 and cytokine-inducible SH2 domain protein (CIS or CISH) [50, 51].”
• Suppressors of cytokine signaling and immunity (2003, background): “Several members of the SOCS and cytokine-inducible SH2 protein (CIS) family of intracellular proteins regulate the responses of immune cells to cytokine”
• The JAK/STAT signaling pathway (2004, positive): “SOCS proteins are a family of at least eight members containing an SH2 domain and a SOCS box at the Cterminus (reviewed by Alexander, 2002).”
• Evasion of intracellular host defence by hepatitis C virus (2005, background): “The SOCS proteins are best known for their role as negative regulators and inhibitors of Jak–STAT signalling, where they mediate a classic negative feedback loop on IFN-α/β receptor signalling event”