The Development of the Concept of Ferroptosis
By Tal Hirschhorn, Brent R. Stockwell. Free Radical Biology & Medicine, 2018
905 citations recorded by the source corpus.
The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species; this type of cell death was found to have molecular characteristics distinct from other forms of regulated cell death. Features of ferroptosis have been observed periodically over the last several decades, but these molecular features were not recognized as evidence of a distinct form of cell death until recently. Here, we describe the history of observations consistent with the current definition of ferroptosis, as well as the advances that contributed to the emergence of the concept of ferroptosis. We also discuss recent implications and applications of manipulations of the ferroptotic death pathway.
Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/b0321f56bfc39c1075be5dfb7c9e802819af4b9a
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In Pulmonary and Respiratory Medicine
Citations in the corpus
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis (2019, background): “While the term “ferroptosis” was coined in 2012, much of the key evidence supporting this mode of cell death has been accumulating over the past few decades [8].”
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Excitingly, new forms of RCD have been extensively studied in the past decade; these modalities include necroptosis [22], pyroptosis [23], and ferroptosis [24].”