Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals.

By T. Ohno-Shosaku, T. Maejima, Masanobu Kano. Neuron, 2001

849 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/4659a5534893292ac916131acc0c50c98b88c470

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Pertwee
2. K. Mackie
3. V. Di Marzo
4. R. Ross
5. George Kunos
6. E. Rancz
7. Tamás F. Freund
8. I. Katona

In Cognitive Neuroscience

1. R. Pertwee
2. K. Mackie
3. E. Rancz
4. V. Di Marzo
5. P. Castillo
6. Tamás F. Freund
7. R. Ross
8. George Kunos

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. K. Mackie
4. George Kunos
5. Tamás F. Freund
6. R. Ross
7. P. Pacher
8. S. Batkai

Citations in the corpus

• Cannabinoid receptors and their ligands. (2002, positive): “52,88,102 K The effect of DSI on evoked inhibitory postsynaptic currents can be mimicked by the endocannabinoid membrane transport inhibitor, AM404, in an SR141716A-sensitive manner.”
• Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission (2001, background): “…synaptic level has been emphasized by recent discoveries in the hippocampus and cerebellum, suggesting that endocannabinoids may act as retrograde synaptic messengers on presynaptic CB1 receptors (Kreitzer and Regehr, 2001; Ohno-Shosaku et al., 2001; Wilson and Nicoll, 2001; Wilson et al., 2001).”
• Postsynaptic endocannabinoid release is critical to long-term depression in the striatum (2002, background): “Endocannabinoids act as retrograde signals mediating transient, depolarization-induced synaptic inhibition in hippocampu”
• Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “However, when the readout of the physiological experiment was highly specific (for example, in paired recordings, when the measured synaptic currents originated from a single presynaptic neuron), the activation of CB 1 receptors could almost entirely block neurotransmitter release from both glutama”
• International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors (2002, background): “In the hippocampus, such release seems to take place from pyramidal cells (Ohno-Shosaku et al., 2001; Wilson and Nicoll, 2001).”
• Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism (2003, background): “Retrograde regulation of the synaptic release of glutamate and GABA by endocannabinoids is emerging as a widespread modulatory mechanism at synapses throughout the brain, including the hippocampus, cerebellum, striatum, and neocortex (Huang et al., 2001; Ohno-Shosaku et al., 2001 ).”