Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism

By S. Di, Renato Malcher-Lopes, K. Halmos, J. Tasker. Journal of Neuroscience, 2003

801 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1c4e28ed20539faa7a3cd2fc593208cc1620f6f8

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Citations in the corpus

Endocannabinoid control of food intake and energy balance (2005, background): “Additionally, in the PVN postsynaptic endocannabinoids retrogradely inhibit glutamatergic release from presynaptic neurons, thus mediating corticosterone-induced fast inhibition of CRH release in this nucleu”
Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “In the PVN, eCB synthesis can be driven by glucocorticoids ; this results in a presynaptic decrease in glutamate release (Di et al, 2003; Wamsteeker et al, 2010), which contributes to dampening HPA axis activity following stress (Evanson et al, 2010).”
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “In contrast, there are also examples of negative modulation of HPA function by endocannabinoids (Di et al., 2003; Patel et al., 2004).”
Stress and the brain: from adaptation to disease (2005, background): “and also in the hypothalamus, which involve endocannabinoid”
Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. (2005, background): “Membrane glucocorticoid binding has been observed in non-mammalian species (Orchinik et al., 1991), and it is clear that glucocorticoids have rapid effects on glutamate signaling in the PVN (see (Di et al., 2003).”
Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “In this structure, glucocorticoids evoke an endocannabinoid-mediated depression of excitatory inputs on parvocellular neurosecretory neuron”
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response (2016, positive): “The released ECs bind CB1 receptors on presynaptic terminals, inhibiting glutamate release and thereby reducing drive to CRH neurons (both in vitro and in vivo ) (37,42).”
The emerging role of the endocannabinoid system in endocrine regulation and energy balance. (2006, background): “The same inhibitory mechanism mediated by glucocorticoids through an activation of the endocannabinoid system has also been proposed for other hormones and neuropeptides such as oxytocin and vasopressin (103).”
Stress, eating and the reward system. (2007, background): “The relationship between cortisol and food intake in humans may also involve effects of glucocorticoids on Neuropeptide Y (NPY), CRH [45], leptin [32] as well as opioid [46] and endocannabinoid [47] signaling, as described inmore detail below.”
Chronic stress and comfort foods: self-medication and abdominal obesity. (2005, background): “A recent study from Tasker's lab showed in hypothalamic slices that dexamethasone infusion activated cannabinoid secretion from CRF neurons; the cannabinoids acted locally on CB-1 cannabinoid receptors on aVerent glutamatergic axon terminals to block input to the CRF cells (Di et al., 2003).”