International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

By Allyn C. Howlett, F. Barth, T. Bonner, G. Cabral, P. Casellas, W. Devane, C. Felder, M. Herkenham, K. Mackie, B. Martin and 2 more. Pharmacological Reviews, 2002

2,760 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/6da89a228eb74dba325a74ad0fa25504c73fcbea

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Pertwee
2. V. Di Marzo
3. U. Kumar
4. Shenglong Zou
5. R. Ross
6. George Kunos
7. T. Klein
8. Marilyn Huestis

In Cognitive Neuroscience

1. R. Pertwee
2. U. Kumar
3. Shenglong Zou
4. V. Di Marzo
5. L. Parker
6. Hui-Chen Lu
7. K. Mackie
8. R. Ross

In Pharmacology

1. R. Pertwee
2. V. Di Marzo
3. U. Kumar
4. Shenglong Zou
5. T. Klein
6. George Kunos
7. P. Pacher
8. S. Batkai

Citations in the corpus

• Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “Despite only CB1R and CB2R are widely-acknowledged as CBRs, several other receptors, ranging from other G protein-coupled receptors (GPCRs) to ion channel and nuclear receptors, have been reported to interact with cannabinoids [9,10].”
• Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration (2003, background): “The marijuana plant, Cannabis sativa, contains Ͼ60 cannabinoid compounds, the best known being ⌬ 9 -tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) (for review, see Howlett et al., 2002).”
• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. (2003, background): “On the basis of the observation that CB1 and endocannabinoids are present in the brain regions controlling food intake (4), the endogenous cannabinoid system has been proposed as a putative modulator of feeding behavior (12, 13).”
• An introduction to the endogenous cannabinoid system (2015, background): “Both CB1 and CB2 cannabinoid receptors are G protein-coupled receptors (GPCR’s), which primarily couple to G proteins of the Gi and Go classes (4).”
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin (2008, methodology): “Among the effects that D9-THC seems to produce in vivo in healthy animals by activating neuronal CB1 receptors are several that are frequently used as measured responses in bioassays for CB1 receptor agonists (reviewed in Howlett et al., 2002; Pertwee, 2006).”
• The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis (2004, background): “D-9-THC The psychotropic effects of D-9-THC are mediated by partial agonist effects at CB-1 receptors (CB-1R) where it has modest affinity (Ki¼ 35–80 nmol) and low intrinsic activity (Compton et al, 1992; Gerard et al, 1991; Howlett et al, 2002; Matsuda et al, 1990).”
• Cannabinoid pharmacology: the first 66 years (2006, background): “For the cannabinoids, two bioassays that proved to be successful measured ‘static ataxia’ in dogs and changes such as sedation, ptosis and body sag in monkeys (reviewed in Howlett et al., 2002).”
• International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 (2010, methodology): “As to CB 2 receptors, these are located predominantly in immune cells and, when activated, can modulate immune cell migration and cytokine release both outside and within the brain (for review, see Howlett et al., 2002; Cabral and Staab, 2005; Pertwee, 2005a).”
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “1B) (Howlett et al., 2002), as well as the subsequently discovered endogenous arachidonic acid derivatives or endocannabinoids (Fig.”
• Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability. (2003, neutral): “…reactivation of presynaptic glutamatergic fibers can induce duce voltage-dependent Ca2 currents, and modulate long-term depression of hippocampal inhibitory syn- several K conductances (Howlett et al., 2002; Schlicker apses via retrograde cannabinoid signaling (Figure 9A). and Kathmann, 2001).”