An internal thermal sensor controlling temperature preference in Drosophila

By F. Hamada, M. Rosenzweig, KyeongJin Kang, S. Pulver, Alfredo Ghezzi, T. Jegla, P. Garrity. 2008

1,049 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Genetics

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, methodology): “We also assayed the behavior of flies from each split-GAL4 driver line in a high-throughput openfield arena described in (Kabra et al., 2013) for 15 min during dTrpA1 activation using 10X UASdTRPA1 (attP16) (Hamada et al., 2008) at 30°C.”
Dopamine Is Required for Learning and Forgetting in Drosophila (2012, positive): “We drove expression of a UAS-shi transgene encoding a temperature-sensitive Dynamin protein that blocks synaptic output at restrictive temperatures (Kitamoto, 2001) or a UAS-trpA1 transgene encoding a temperature-sensitive cation channel to stimulate DANs at elevated temperatures (Hamada et al., 200”
Competing dopamine neurons drive oviposition choice for ethanol in Drosophila (2013, background): “To confirm that PPL1 neurons suppress oviposition preference, we expressed the temperature-sensitive cation channel dTrpA1 (37) in the MB-MP1 PPL1 cells.”
Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory (2015, methodology): “We conducted neuronal activation experiments by using the two Gal4 drivers NP2397 and R76B09 to express UAS-dTRPA1, which encodes a heat-activated cation channel (58) that stimulates neurons at a moderately warm temperature (>25 °C).”
Distinct dopamine neurons mediate reward signals for short- and long-term memories (2014, methodology): “We activated different sets of PAM cluster neurons by thermogenetic stimulation with a temperature-sensitive cation channel dTrpA1 (35) in the presence of an odor and evaluated reward signals behaviorally by measuring appetitive odor memory immediately (STM) or 24 h after training (LTM).”
Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila (2011, background): “In addition to the discovery of these thermo-TRP channels, various genetic studies to understand the brain center, and the responsible neuromodulators and neural circuits of TPB in Drosophila have been actively pursued [1,5,16].”
Sleep facilitates memory by blocking dopamine neuron mediated forgetting (2015, neutral): “Furthermore, stimulation of these neurons, using UAS-trpA1 (Hamada et al., 2008), did not produce genotype specific and robust increases in locomotor activity (Figures S1D and S1F).”
Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. (2013, methodology): “As a first insight into this point, we performed an experiment where MB-V3 neurons were artificially activated during memory retrieval, through the thermosensitive cation channel dTrpA1 (Hamada et al., 2008; Plaçais et al., 2012).”
Organization of antennal lobe‐associated neurons in adult Drosophila melanogaster brain (2012, background): “…of the antennae, thermosensitive neurons in the antennal nerve, and neurons projecting via The Journal of Comparative Neurology | Research in Systems Neuroscience 4125 the pharyngeal nerve (Stocker et al., 1990; Itoh et al., 1991; Shanbhag et al., 1995; Hamada et al., 2008; Gallio et al., 2011).”
A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila. (2012, neutral): “We expressed the temperaturesensitive cation channel dTRPA1 in the ab4B neurons, a proce- 1348 Cell 151, 1345–1357, December 7, 2012 ª2012 Elsevier Inc. dure that allowed us to conditionally activate these OSNs at temperatures >26 C (Hamada et al., 2008).”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, methodology): “For activation of target neurons, we expressed the thermo-sensitive cation channel dTRPA1 [34].”
Propagation of homeostatic sleep signals by segregated synaptic microcircuits of the Drosophila mushroom body (2015, neutral): “Each of these splitGAL4 lines (or a negative control ‘‘empty’’ split-GAL4 line, pBDPGAL4U, lacking active genomic enhancer sequences) was crossed to a UAS-dTRPA1 line to drive expression of the temperature-gated depolarizing cation channel dTRPA1 [20].”
Short neuropeptide F is a sleep-promoting inhibitory modulator (2013, methodology): “Activation of sNPF Neurons Rapidly Increases Sleep Independent of Changes in Locomotion To test the role of different subsets of adult brain peptidergic neurons in sleep (Figure 1A), we used the warmth-activated dTRPA1 cation channel to acutely activate nine different peptidergic neuron classes (Ham”
Specific dopaminergic neurons for the formation of labile aversive memory (2010, neutral): “For behavioral assay, F1 progenies of the crosses between females of UAS-shi (X, III) [28], UASdTrpA1(II) [37], UAS-dTrpA1 TH-GAL80 (II) [39], UAS-dTrpA1;ChaGAL80 (II, III) [41], or white and males of NP5272 (II) [22], NP1528 (II) / CyO [22], NP2758 (X) [22], NP6510 (III) [22], MZ840 (III), or TH-GA”
Drosophila Learn Opposing Components of a Compound Food Stimulus (2014, background): “The wild-type Canton-S [23], c061; MBGAL80 [23], TbhM18 [20], dumb1 [21], UAS-shits1 [22], R73F07-GAL4 [24], NP1528-GAL4 [6], NP5272-GAL4 [6], UAS-dTrpA1 [19], Gr66a-GAL4 [34], UAS-hid:UAS-rpr [17], UAS-GCaMP3 [26], TH-GAL4 [27], and UAS-IR40aRNAi [12] flies have all been described.”
Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila (2015, background): “The dTrpA1-encoded transient receptor potential (TRP) channel conducts Ca and depolarizes neurons when temperature exceeds 25 C [16].”
Converging circuits mediate temperature and shock aversive olfactory conditioning in Drosophila. (2014, positive): “We detected GRASP signals in the posterior protocerebrum, the region where the AC neurons heavily terminate (Figures 6E and 6F) [14].”