Short neuropeptide F is a sleep-promoting inhibitory modulator
By Yuhua Shang, Nathan C. Donelson, C. Vecsey, F. Guo, M. Rosbash, Leslie C. Griffith. 2013
138 citations recorded by the source corpus.
SUMMARY To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep-induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons and flies even experience negative sleep rebound upon cessation of sNPF neuronal stimulation, indicating that sNPF provides an important signal to the sleep homeostat. Only a subset of sNPF-expressing neurons, which includes the small ventrolateral clock neurons, is sleep-promoting. Their release of sNPF increases sleep consolidation in part by suppressing the activity of wake-promoting large ventrolateral clock neurons, and suppression of neuronal firing may be the general response to sNPF receptor activation. sNPF acutely increases sleep without altering feeding behavior, which it affects only on a much longer time scale. The profound effect of sNPF on sleep indicates that it is an important sleep-promoting molecule.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Endocrine and Autonomic Systems
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
- Yoshinori Aso
- Gerald M. Rubin
- Hiromu Tanimoto
- P. Plaçais
- T. Préat
- M. Nitabach
- Nobuhiro Yamagata
- Toshiharu Ichinose
In Cognitive Neuroscience
- Yoshinori Aso
- Gerald M. Rubin
- Nobuhiro Yamagata
- Leslie C. Griffith
- Toshiharu Ichinose
- Hiromu Tanimoto
- Paula Haynes
- B. Christmann
In Endocrine and Autonomic Systems
Citations in the corpus
- Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “, 2013) and hyperpolarizes cells expressing the sNPF receptor (Shang et al., 2013).”
- A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster (2015, background): “The negative sleep rebound after release is consistent with the presence of strong compensatory homeostatic mechanisms counteracting excessive sleep (Shang et al., 2013) and/or excessive DPM activity.”