Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

By Elisabeth B. Binder, D. Salyakina, P. Lichtner, G. Wochnik, M. Ising, B. Pütz, S. Papiol, S. Seaman, S. Lucae, M. Kohli and 29 more. Nature Genetics, 2004

973 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/463fd85fa1d2e246124db2045e21771b26fbbf02

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In Behavioral Neuroscience

In Endocrinology, Diabetes and Metabolism

In Physiology

Peter W. Kalivas

Citations in the corpus

Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. (2008, background): “This environment-dependent reversal of the functional association may be similar to the effects previously reported in patients with depression, where less cortisol response in the dexamethasone-CRH test (an indication of increased GR sensitivity) was observed with the same alleles that had been ass”
New approaches to antidepressant drug discovery: beyond monoamines (2006, background): “Some patients with depression carry a polymorphism, or genetic variant, in the FKBP5 gene (which encodes a co- chaperone of heat-shock protein 90 (HSP90)) that results in higher affinity of GR for cortiso”
Stress and the brain: from adaptation to disease (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2289"> FKBP5 gene, which encodes a co-chaperone of heat-shock protein 90 (HSP90), responded much faster to antidepressants than a group that did not carry this mutatio”
The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. (2009, background): “This finding is, however not supported by reports by (Binder et al., 2004; Papiol et al., 2007), although the negative results from these studies might be related to lack of power.”