Tumor delivery of macromolecular drugs based on the EPR effect.

By Vladimir Torchilin. Advanced Drug Delivery Reviews, 2011

1,895 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/4508a3872eacd4e1b3d171252a27c373451f1c97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. S. Mitragotri
2. A. Anselmo
3. Jun Wu
4. S. Biswas
5. Pranali P. Deshpande
6. O. Farokhzad
7. N. Bertrand
8. Xiaoyang Xu

In Molecular Biology

1. O. Farokhzad
2. S. Biswas
3. Pranali P. Deshpande
4. N. Bertrand
5. Jun Wu
6. S. Mitragotri
7. Xiaoyang Xu
8. A. Anselmo

In Polymers and Plastics

1. Jun Wu
2. A. Molinari
3. S. Mitragotri
4. A. Anselmo
5. Giuseppina Bozzuto
6. N. Bertrand
7. N. Anton

Citations in the corpus

• Treating metastatic cancer with nanotechnology (2011, background): “Consequently, some solid tumours will exhibit the enhanced permeation and retention (EPR) effect whereby nanomaterials may accumulate in the tumour and be retaine”
• Liposomes as nanomedical devices (2015, background): “84 The enhanced permeation and retention (EPR) effect is the phenomenon characterizing malignant tissues by which nanocarriers of an appropriate size can pass through tumor-vessel walls and enter the neoplastic lesion (Figure 2).”
• Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “These new blood vessels are leaky as they have large pores that lead to poor perm-selectivity of tumor blood vessels compared to the normal blood vessels [29, 30].”
• Current trends in the use of liposomes for tumor targeting (2013, background): “Targeting of these drugs relies solely on the pathophysiological properties of the tumor tissues, and is referred to as `passive drug targeting' [8,13,14].”
• Nanoparticles in the clinic (2016, background): “, tumors via EPR effect).(39,110,111) Similar effects can be achieved using hydrophilic sugar (e.”
• Nanocarriers for drug delivery applications (2018, background): “This effect is known as the enhanced permeability and retention effect explained by Matsumura and Maeda in 1986 (Haley and Frenkel 2008; Torchilin 2011).”
• An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “For this purpose, watersoluble polymers (generally PEGs) are grafted on the nanocarrier surface.([10,24]) Moreover, PEGylation prevents nanoparticle aggregation and non-specific interactions by changing surface charge and hydration.”