Nanoparticles in the clinic
By A. Anselmo, S. Mitragotri. Bioengineering & Translational Medicine, 2016
1,116 citations recorded by the source corpus.
Abstract Nanoparticle/microparticle‐based drug delivery systems for systemic (i.e., intravenous) applications have significant advantages over their nonformulated and free drug counterparts. For example, nanoparticle systems are capable of delivering therapeutics and treating areas of the body that other delivery systems cannot reach. As such, nanoparticle drug delivery and imaging systems are one of the most investigated systems in preclinical and clinical settings. Here, we will highlight the diversity of nanoparticle types, the key advantages these systems have over their free drug counterparts, and discuss their overall potential in influencing clinical care. In particular, we will focus on current clinical trials for nanoparticle formulations that have yet to be clinically approved. Additional emphasis will be on clinically approved nanoparticle systems, both for their currently approved indications and their use in active clinical trials. Finally, we will discuss many of the often overlooked biological, technological, and study design challenges that impact the clinical success of nanoparticle delivery systems.
Subfields: Biomaterials, Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/0b26ef6ad32f75fad973edf394b68af99f48d4cc
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In Biomaterials
In Biomedical Engineering
In Materials Chemistry
Citations in the corpus
- Nanoparticles in the clinic: An update (2019, background): “, scale-up limitations, parameter optimization, and predicting efficacy), and clinical challenges that have limited the translation of nanoparticles.(1) In these past 3 years, since that article was published, two intravenously administered nanoparticles have been FDA and EMA approved, one intratumo”
- Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer (2018, background): “The absorption of light leads to an increase in the local temperature, which thermally dissolves the solid tumors [73].”
- Smart nanoparticles for cancer therapy (2023, background): “286,287 290 Previous research revealed that PEG coating is a useful technology for increasing the retention of particles in tumor sites and extending the circulating half-life of particles.”