Current trends in the use of liposomes for tumor targeting

By Pranali P. Deshpande, S. Biswas, Vladimir Torchilin. Nanomedicine, 2013

613 citations recorded by the source corpus.

The use of liposomes for drug delivery began early in the history of pharmaceutical nanocarriers. These nanosized, lipid bilayered vesicles have become popular as drug delivery systems owing to their efficiency, biocompatibility, nonimmunogenicity, enhanced solubility of chemotherapeutic agents and their ability to encapsulate a wide array of drugs. Passive and ligand-mediated active targeting promote tumor specificity with diminished adverse off-target effects. The current field of liposomes focuses on both clinical and diagnostic applications. Recent efforts have concentrated on the development of multifunctional liposomes that target cells and cellular organelles with a single delivery system. This review discusses the recent advances in liposome research in tumor targeting.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/77c170c3ce90c07d01e2b1b681cf9f705a3acaba

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In Biomaterials

In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Nanocarriers for drug delivery applications (2018, background): “The use of folate ligands has the advantage of its small size with molecular weight ~ 441 kDa than the antibodies with molecular weight ~ 160,000 kDa (Deshpande et al. 2013).”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “In cancer treatment, the use of temperature-sensitive liposomes would involve local heating of the tumor site to trigger liposomal drug release (Deshpande et al., 2013).”
Advances and Challenges of Liposome Assisted Drug Delivery (2015, background): “The cells of the RES are also part of the innate immune system, which has raised the question of whether macrophage saturation by liposomes leads to immunosuppression and increases the risk of infections.”
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors (2017, background): “19 Drug-loaded liposome preparations control the drug distribution within plasma, thus leading to improved biodistribution and pharmacokinetics of drugs.”