Towards a molecular understanding of microRNA-mediated gene silencing

By S. Jonas, Elisa Izaurralde. Nature reviews genetics, 2015

1,761 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4406700b3af05f27d544b33f4bca7e13f506232f

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Citations in the corpus

The Functions of MicroRNAs: mRNA Decay and Translational Repression. (2015, background): “For more details on the structural bases for the interactions between GW182 and its interactors, see Jonas and Izaurralde [143].”
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (2018, background): “C), Argonautes (AGO1–3; reviewed in Jonas and Izaurralde, 2015), 4E-T (EIF4ENIF1), and 4EHP (EIF4E2) (Nishimura et al., 2015; Ozgur et al., 2015), as expected.”
Translational Control in Cancer. (2018, background): “All of these elements have been thoroughly reviewed elsewhere (Komar and Hatzoglou 2011; Jonas and Izaurralde 2015; Wurth and Gebauer 2015; Hinnebusch et al. 2016; Truitt and Ruggero 2016) and are described by Duchaine and Fabian (2018).”
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “However, in human cells, about 60% of the interactions between the miRISC complex and mRNA are non-canonical [27], which means that their chains are not always entirely complementary [28].”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “The formation of a silencing miRISC complex starts with the recruitment of the GW182 family of proteins by miRISC; GW182 provides the scaffolding needed to recruit other effector proteins (52), such as the poly(A)-deadenylase complexes PAN2-PAN3 and CCR4-NOT, following miRNA:target mRNA interaction ”
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions (2016, background): “Thus, several authors have explored the details of the mechanistic events and protein effectors regulating miRNA mediated target decay and translational repression shedding light on miRISC activity in the cytoplasm (for a review see Jonas and Izaurralde [35]).”
mirDIP 4.1—integrative database of human microRNA target predictions (2017, background): “The binding results in accelerated mRNA degradation, translational repression, mRNA deadenylation or mRNA destabilization (2), and can interfere with translation initiation, re-press translation elongation and termination, or recruit co-factors involved in protein degradation and sequestration (4).”
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways (2018, background): “The unprotected 5ʹend is degraded by 5ʹ–3ʹ exoribonuclease 1 (not shown) (reviewed in ref.(182)).”
Metazoan MicroRNAs (2018, background): “…to be less efficiently translated, an effect on translation initiation thought to be mediated, at least in part, by CCR4-NOT and its recruitment of DDX6, a helicase that binds the decapping complex and is reported to inhibit translation (Chu and Rana, 2006; Jonas and Izaurralde, 2015) (Figure 4).”
The biochemical basis of microRNA targeting efficacy (2018, background): “Each miRNA associates with an Argonaute (AGO) protein to form a silencing complex, in which the miRNA pairs to sites within target transcripts and the AGO protein promotes destabilization and/or translational repression of bound transcripts (2).”