Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

By D. Shedlock, Hao Shen. Science, 2003

1,666 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/43fbe2608853b437931c3ba81bc3c11df3a2d2c2

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In Immunology

Citations in the corpus

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death (2005, background): “jpg" NDATA ITEM> ]> The ‘help’ provided by CD4 p T lymphocytes during the priming of CD8 p T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antige”
Toll-like receptor control of the adaptive immune responses (2004, background): “Primary activation of CD8 + T cells requires similar signals from the DCs, whereas memory CD8 + T cell responses require CD4 + T cell hel”
Immune responses to Listeria monocytogenes (2004, background): “, CD4 + T cells have been suggested to be important during the initial priming process, in which they provide CD8 + T cells with the ability to vigorously proliferate after re-encountering antigen many months late”
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon (2003, background): “This was notable, given reports that some 'CD4-dependent' CD8 responses in fact are defective only in terms of their ability to make a secondary response to antige”
Adoptive-cell-transfer therapy for the treatment of patients with cancer (2003, background): “The recent reports describing a requirement of CD4 + T cells for persistence of CD8 + T cells after an immune respons”
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “Although CD4 + T cells are not required for primary CD8 + T cell responses against pathogens, memory CD8 + T cell numbers and secondary responses to bacterial or viral challenge are decreased over time in a CD4 + T cell–deficient anima”
Th17 cells promote cytotoxic T cell activation in tumor immunity (2009, background): “Given that CD4 T cell help is essential for the generation of CD8 memory T cells during the priming phase of an acute viral infection (Shedlock and Shen, 2003), it is possible that Th17 cells may participate in this process via the generation of CD8 antitumor effector-memory T cells.”
Dendritic cells as therapeutic vaccines against cancer (2005, background): “In particular, CD4 + T cells seem to be crucial for priming long-lived CD8 + T-cell memor”