ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

By Xiaobing Shi, T. Hong, Kay L. Walter, Mark Ewalt, E. Michishita, T. Hung, Dylan Carney, P. Peña, F. Lan, Mohan R. Kaadige and 11 more. Nature, 2006

1,021 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/42e870b3c06b6a8d2f70da3713ab3e24ee162ec9

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In Molecular Biology

1. Yi Zhang
2. Yang Shi
3. C. D. Allis
4. J. Whetstine
5. Xiang-Jiao Yang
6. A. Shilatifard
7. E. Seto
8. Jerry L. Workman

Citations in the corpus

• The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, positive): “Finally, all four members contain the PHD domain, which has recently been shown to be a histonemethyl-lysine binding motif (Shi et al., 2006; Wysocka et al., 2006).”
• Covalent histone modifications: miswritten, misinterpreted, and miserased in human cancers (2010, background): “A recent breakthrough was the discovery of a specialized group of protein modules, plant homeodomain (PHD) fingers ( Box 2 ), which function as the specific reading motif for trimethylated and dimethylated H3K4 (H3K4me3/2), with H3K4me3 as the preferred ligan”
• The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “Interestingly, ING2 recognizes K4-methylated histone H3 and targets the Sin3A complex to deacetylate nucleosomes in a methylation-dependent manne”
• Development of a quantum dots FRET-based biosensor for efficient detection of Polymyxa betae (2012, neutral): “, 2006 ), detection of protein (Algar & Krull, 2007 ) and inter-molecular binding assays (Willard et al.”
• Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression (2007, background): “The differentially methylated lysine residues serve as docking sites for various effector proteins and chromatin modifiers, which results in diverse physiological responses, such as transcriptional repression and activatio”
• The Language of Histone Crosstalk (2010, background): “The Yng1-related ING2 can also bind methylated H3K4; however, it is present in a histone deacetylase complex (Shi et al., 2006).”
• Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. (2007, background): “Several papers described interactions between PHD fingers containing proteins (including BPTF) and methylated H3K4 or H3K36 peptides (Li et al., 2006; Pena et al., 2006; Shi et al., 2006; Wysocka et al., 2006).”