The Language of Histone Crosstalk

By Jung-Shin Lee, Edwin R. Smith, A. Shilatifard. Cell, 2010

605 citations recorded by the source corpus.

It has been suggested that a specific pattern of histone posttranslational modifications and their crosstalk may constitute a code that determines transcriptional outcomes. However, recent studies indicate that histone modifications have context-dependent effects, making their interplay more like a language within the chromatin signaling pathway than a code.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/abe8e819f4269e1facaca70f0ea9819dbd97302e

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Citations in the corpus

Integrative epigenomic mapping defines four main chromatin states in Arabidopsis (2011, background): “In particular, different histone modifications are thought to act sequentially or in combination in order to confer distinct transcriptional outcomes (Strahl and Allis, 2000; Jenuwein and Allis, 2001; Berger, 2007; Lee et al, 2010a).”
Multidimensional proteomics for cell biology (2015, background): “This is exemplified by the complex set of modifications that may be imparted to histones — sometimes termed the histone code — in order to modulate chromatin function 96 .”
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis (2012, neutral): “Histone modifications can influence one another, such that onemodification is required for the generation of a different modification for subsequent gene transcription regulation (Lee et al., 2010; Suganuma and Workman, 2008).”
Cancer epigenetics: from mechanism to therapy. (2012, background): “’’ The combinatorial influence that one or more histone modifications have on the deposition, interpretation, or erasure of other histone modifications has been broadly termed ‘‘histone crosstalk,’’ and recent evidence would suggest that crosstalk is widespread and is of great biological significanc”
Transcriptional Addiction in Cancer (2017, neutral): “The roles of these diverse chromatin regulators in gene control have been reviewed extensively elsewhere (Campos and Reinberg, 2009; Kouzarides, 2007; Lee et al., 2010; Piunti and Shilatifard, 2016; Soshnev et al., 2016; Tessarz and Kouzarides, 2014).”
Global Quantitative Modeling of Chromatin Factor Interactions (2014, background): “Histone modifications are known to facilitate or repress each other through crosstalk [3], and our modeling approach provides a systematic way to analyze crosstalk patterns.”
The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “It will also be revealing to determine whether Erk signaling may cause activation of pTEFb (Fujita et al., 2008; Lee et al., 2010).”