NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

By S. Luquet, FranciscoA . Perez, T. Hnasko, R. Palmiter. Science, 2005

1,093 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Social Psychology

View Paper: https://www.semanticscholar.org/paper/41fd1e2e7a32033df695a824ad91d4017c8df9fa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Bryan L. Roth
2. S. Waddell
3. C. Ye
4. J. Flier
5. A. N. van den Pol
6. M. Krashes
7. Bradford B. Lowell

In Nutrition and Dietetics

1. Bryan L. Roth
2. J. Flier
3. A. N. van den Pol
4. Bradford B. Lowell
5. A. Basbaum

In Social Psychology

1. David J. Anderson
2. A. N. van den Pol

Citations in the corpus

• Leptin regulation of the mesoaccumbens dopamine pathway. (2006, positive): “…involving leptin signals within POMC and NPY/AgRP neurons in the arcuate nucleus have been defined through functional neuroanatomy and genetic gain-and loss-of-function approaches (Erickson et al., 1996; Elias et al., 1999; Balthasar et al., 2004; Elmquist et al., 2005; Luquet et al., 2005).”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, positive): “, 1997), and the neurons that express them (POMC and AgRP neurons which are located primarily in the arcuate) (Bewick et al., 2005; Gropp et al., 2005; Luquet et al., 2005; Xu et al., 2005), play key roles in regulating body weight.”
• A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “Most impressively, ablation of NPY-expressing neurons from adult mice leads to starvation (Bewick et al., 2005; Gropp et al., 2005; Luquet et al., 2005).”
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli (2009, methodology): “S3), suggesting that other nociceptor populations can functionally compensate for the loss of Mrgprd neurons, but only if the loss occurs sufficiently early in development (18).”
• Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. (2011, background): “Conversely, acute ablation of AgRP neurons in adult mice, a manipulation associated with gliosis (5), induces severe hypophagia (7, 8).”
• Semaglutide lowers body weight in rodents via distributed neural pathways. (2020, background): “Inhibition of the PB by hypothalamic AgRP neurons is involved in the regulation of food intake (31, 95–97): silencing AgRP neurons elicits a robust PB c-Fos response, leading to starvation of animals and ultimately death (96, 98).”
• Neuropeptide transmission in brain circuits (2012, background): “However, selective loss of AgRP/NPY neurons in the adult led to a cessation of feeding and death (Luquet et al., 2005; Gropp et al., 2005), suggesting that NPY and AgRP, while important modulators of food intake, are only part of the transmitter puzzle regulating energy homeostasis, and that other s”
• Deconstruction of a neural circuit for hunger (2012, neutral): “10 pA (6) (11) (5) (5) (7) (5) (11) (5) (5) (7)”