Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

By M. Krashes, S. Koda, C. Ye, Sarah C. Rogan, A. Adams, Daniel S Cusher, E. Maratos-Flier, Bryan L. Roth, Bradford B. Lowell. Journal of Clinical Investigation, 2011

1,426 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c859ce20ffbe169a7d73586c21b96b4b885f10b7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Bryan L. Roth
2. A. N. van den Pol
3. Bradford B. Lowell

In Endocrine and Autonomic Systems

1. Bryan L. Roth
2. A. N. van den Pol
3. Bradford B. Lowell
4. Haiming Cao
5. G. Hotamışlıgil

In Molecular Biology

1. Bryan L. Roth
2. Steven A. McCarroll
3. E. Rosen
4. A. N. van den Pol
5. Bradford B. Lowell
6. B. Spiegelman
7. G. Hotamışlıgil

Citations in the corpus

• DREADDs for Neuroscientists (2016, methodology): “This phenomenon might explain why no significant desensitization was seen when DREADDs were virally or transgenically expressed (Alexander et al., 2009; Krashes et al., 2011)”
• Deconstruction of a neural circuit for hunger (2012, neutral): “10 pA (6) (11) (5) (5) (7) (5) (11) (5) (5) (7)”
• A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types (2017, methodology): “We next determined whether chemogenetic activation of ARC SST neurons could affect feeding, as has been robustly shown for AgRP neurons 4 .”
• Neuropeptide transmission in brain circuits (2012, background): “Selective activation of the NPY/AgRP neuron with DREADD (designer receptors exclusively activated by designer drugs; Rogan and Roth, 2011) receptors increased feeding and reduced energy expenditure (Krashes et al., 2011).”
• Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet. (2017, background): “AC CE PT ED M AN US CR IP T targeted infusions of orexin and/or orexin agonists into the brain, the use of DREADDs allows for the sustained activation of these neurons on the order of hours without needing to inject directly into the brain [17, 18].”
• A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior (2015, neutral): “Following light cycle food restriction, food consumption was monitored during the first 60 min of the dark cycle, when mice normally eat and ARCAgRP neural activity is high (Krashes et al., 2011; Krashes et al., 2013).”