Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

By A. Neish, A. Gewirtz, H. Zeng, A. Young, M. Hobert, V. Karmali, A. S. Rao, J. Madara. 2000

840 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/41bc07b0e38f4c528abe705a4a792e929177892a

How researchers see this paper

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In Cancer Research

1. P. Allavena

In Immunology

1. L. Hooper
2. P. Sansonetti
3. R. Peek
4. Jeffrey I. Gordon
5. A. Mowat
6. M. Rescigno
7. S. Hanauer
8. P. Allavena

In Surgery

1. R. Peek
2. S. Hanauer

Citations in the corpus

• Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells (2005, background): “Future studies should determine whether this mechanism is influenced by the presence of probiotic or commensal bacteria, given their regulatory effect on EC functio”
• The gut flora as a forgotten organ (2006, background): “These include inhibition of epithelial proteasome function, degradation of the NF- B counter-regulatory factor I B or nuclear export of the NF- B subunit, p65, through a peroxisome proliferator-activated receptor (PPAR) -dependent pathway (Kelly et al, 2004; Neish et al, 2000; Petrof et al, 2004).”
• Helicobacter pylori: gastric cancer and beyond (2010, background): “Co-culture of intestinal epithelial cells with nonpathogenic Salmonella typhimurium leads to the activation of β-catenin signalling by the AvrA-mediated blockade of β-catenin ubiquitylatio”
• Microflora of the digestive tract: critical factors and consequences for poultry (2006, background): “However, bacteria can also attenuate the inflammatory response (Neish et al., 2000).”
• Angiogenins: a new class of microbicidal proteins involved in innate immunity (2003, background): “The intestine exhibits a remarkable ability to accommodate a complex society of indigenous microbes without mounting an inflammatory respons”
• War and peace at mucosal surfaces (2004, background): “or tumour-necrosis factor (TNF) — probably by blocking the function of the ubiquitylation complex E3 ubiquitin ligase–β-transducin-repeat-containing protein, which mediates ligation of ubiquitin molecules to the protein targeted for degradatio”
• Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities (2006, background): “2).(3,39,40) In IBD, this tolerance is lost.”