Angiogenins: a new class of microbicidal proteins involved in innate immunity

By L. Hooper, T. Stappenbeck, Chieu V. Hong, Jeffrey I. Gordon. Nature Immunology, 2003

975 citations recorded by the source corpus.

Subfields: Biotechnology, Endocrinology, Immunology

View Paper: https://www.semanticscholar.org/paper/03b6ef8e9c0eefe1ea17e32a1fef4ffde37509c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. D. Artis
2. Ruth E. Ley
3. B. B. Finlay
4. L. Hooper
5. Eran Elinav

In Immunology

1. D. Artis
2. L. Hooper
3. H. Wexler
4. Eran Elinav
5. M. Abreu
6. B. B. Finlay
7. J. Cryan
8. Ted G. Dinan

Citations in the corpus

• Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “In addition, colonization of the intestine by beneficial bacterial communities, through occupation of this environmental niche, competition for nutrients and secretion of antimicrobial peptides, probably provides a degree of protection for the host against rapid colonization by pathogenic microorgan”
• TLR Signaling in the Gut in Health and Disease1 (2005, background): “(32) has demonstrated that luminal bacteria induce expression of microbicidal angiogenins by Paneth cells.”
• Immune adaptations that maintain homeostasis with the intestinal microbiota (2010, background): “For example, intestinal microorganisms provide instructive signals for several aspects of intestinal development, including epithelial cell maturatio”
• The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “For instance, Bacteroides thetaiotaomicron has been shown to induce peptides with bactericidal activity that target other intestinal microbes (Hooper et al., 2003).”
• Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface (2008, background): “Although the vast majority of bacteria are sequestered in the gut lumen, a subpopulation of commensals localizes close to the mucosal surface, in or beneath the mucus layer that overlies the entire epithelium (4).”
• Bacteroides: the Good, the Bad, and the Nitty-Gritty (2007, background): “thetaiotomicron (119), and these molecules may prevent pathogens from colonizing the space.”
• Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease (2011, background): “Nitric oxide (NO), angiogenin 1 (Ang1) and cathelicidin are known to have microbicidal properties,”