RNA polymerase is poised for activation across the genome

By Ginger W Muse, Daniel A. Gilchrist, S. Nechaev, Ruchir R. Shah, J. Parker, Sherry F. Grissom, J. Zeitlinger, K. Adelman. Nature Genetics, 2007

817 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4167dded7fdbefa0ce24c6758cc747310a71d014

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Citations in the corpus

Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “This is that many gene promoters are permanently engaged with Pol II initiation complexes (Guenther et al., 2007; Muse et al., 2007) and may generate 5 0 proximal abortive transcripts (Core and Lis, 2008; Kapranov et al., 2007).”
The RNA polymerase II CTD coordinates transcription and RNA processing. (2012, background): “Pausing is thought to constitute a mechanism to obtain rapid and coordinated transcription during development and in response to external stimuli (Muse et al. 2007; Zeitlinger et al. 2007).”
Pol III binding in six mammalian genomes shows high conservation among amino acid isotypes, despite divergence in tRNA gene usage (2011, neutral): “RNA polymerase II (pol II), which is responsible for protein-coding mRNA synthesis, has been well-characterized to bind in vivo to many regions not actively transcribed due to stalled polymerase activity 19,20 , alternate transcription start sites 21 , and regulated alternative splicing 22 .”
Dynamic regulation of nucleosome positioning in the human genome. (2008, neutral): “Recent data suggest that a significant fraction of Drosophila genes are Cell 132, 887–898, March 7, 2008 ª2008 Elsevier Inc. 889 associated with poised or stalled Pol II (Muse et al., 2007; Zeitlinger et al., 2007).”
Nucleosome positioning and gene regulation: advances through genomics (2009, background): “Indeed, a large fraction of metazoan genes have an initiated, but paused, Pol II immediately upstream of, and in contact with, the +1 nucleosom”
c-Myc regulates transcriptional pause release (2010, background): “Previous studies have shown that loss of NELF causes a decrease in Pol II density at promoters, and thus a decrease in Pol II traveling ratio (or pausing index), at a small number of Drosophila genes (Muse et al., 2007).”
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, background): “Previous studies have shown that loss of NELF causes a decrease in Pol II density at promoters, and thus a decrease in Pol II traveling ratio (or pausing index), at a small number of Drosophila genes (Muse et al., 2007).”
A double take on bivalent promoters. (2013, background): “PHF1 (PCL1), MTF2 (PCL2), and PHF19 (PCL3), orthologs of Drosophila Polycomb-like (PCL), also interact with PRC2 and have been implicated in its recruitment (Margueron and Reinberg 2011; Simon and Kingston 2013).”