Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.

By A. Ridley. Trends in Cell Biology, 2006

1,266 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/415cc713f3d11a6d237d6af32a4e446ddd5900ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Yi Zhong
2. Qian Li
3. A. Ridley
4. P. Chiarugi
5. M. Parri
6. S. Heasman
7. P. Lappalainen
8. Mahmut Yilmaz

In Molecular Biology

1. Yi Zhong
2. A. Ridley
3. P. Chiarugi
4. M. Parri
5. Mahmut Yilmaz
6. S. Heasman
7. P. Lappalainen
8. Qian Li

Citations in the corpus

• EMT, the cytoskeleton, and cancer cell invasion (2009, background): “With regard to migration and invasion and in a simplified view, RhoA induces actin stress fiber formation and regulates cytoskeletal changes affecting cell-cell or cell-matrix adhesion, Rac1 is involved in lamellipodia and membrane ruffle formation, and Cdc42 is involved in filopodia formation [136,”
• Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “RhoB localizes to endocytic vesicles and regulates endocytic traffickin”
• Genetic dissection of active forgetting in labile and consolidated memories in Drosophila (2019, background): “However, Rho GTPases are known to interact with numerous effectors (18, 19), and the downstream pathways that tie Rac1 and Cdc42 to actin remodeling and eventually forgetting are far from fully elucidated.”
• Routes and mechanisms of extracellular vesicle uptake (2014, background): “Rac1 is a GTPase which not only has a major role in macropinocytosis (110), but also in regulation of cell growth, cytoskeletal reorganization, protein kinase activation (111) and epithelial-to-mesenchymal transition (EMT) in cancer (112).”
• Filopodia: molecular architecture and cellular functions (2008, background): “The best-studied mammalian Rho GTPases are Rac1 , CDC42 and RhoA”
• Rac and Rho GTPases in cancer cell motility control (2010, background): “They are endowed with GTP hydrolytic activity, mainly involved in cytoskeleton rearrangements and cell motility, but also involved in cell proliferation, transformation and differentiation [2].”
• Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling (2010, background): “Although free cofilin induces severing of actin filaments and generation of FBEs, cofilin is inactive when phosphorylated or when bound to PI(4,5)P2 (Condeelis, 2001; Ridley, 2006).”
• Rho GTPases in cancer cell biology (2008, background): “RhoQ/TC10 is also implicated in receptor trafficking, particularly of the glucose transporter [63], but whether this accounts for its role in transformation is not known.”
• Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein–protein interactions using global analysis (2009, background): “Since there will be a distribution of separations for the ensemble of donor molecules, it would be most appropriate to consider the fitting of a complex distributed lifetime model to the transient fluorescence signal and recover the distance distribution of fluorophores (Rolinski et al. 2000).”