Rho GTPases in cancer cell biology

By F. M. Vega, A. Ridley. FEBS Letters, 2008

816 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f61bc68698a5698278e905b8036beae7aed74413

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Valerie M. Weaver
2. G. Raposo
3. S. Heasman
4. C. Der
5. K. Rossman
6. Sanjay Kumar
7. Marcello Maggiolini
8. Rosamaria Lappano

In Molecular Biology

1. G. Raposo
2. K. Rossman
3. C. Der
4. S. Heasman
5. A. Ridley
6. Marcello Maggiolini
7. Rosamaria Lappano
8. J. Cherfils

Citations in the corpus

• G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “The oncogenic action of various Rho GTPases correlates with their increased expression and activity in various cancer”
• Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “The small GTPase Rho has long been known to contribute to many steps in cancer progression, including proliferation, evasion of apoptosis, invasion, and metastasis [127].”
• ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. (2009, background): “Growth factor-induced signaling, cytoskeletal rearrangements mediated by the Rhofamily GTPases, and alterations to adhesive and migratory potential of cells all accompany the process of cell invasion [2].”
• Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? (2010, background): “It is now clear that Rho GTPases have a major role in many different aspects of tumorigenesi”
• Targeting mitochondrial glutaminase activity inhibits oncogenic transformation (2010, neutral): “A number of lines of evidence have also implicated Rho GTPases in cell growth and malignant transformation (Vega and Ridley 2008).”
• Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “RhoB is proposed to function as a tumour suppressor as its expression is reduced in tumours and its overexpression inhibits cell growth and survival, invasion and metastasi”