The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

By R. Schofield. 1978

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Pengfei Lu
2. Anne Wilson
3. Linheng Li
4. Guo-li Ming
5. Elaine Fuchs
6. F. Gattazzo
7. S. Gronthos
8. S. Shi

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Neurogenic Niche in the Adult Mammalian Brain First suggested from transplantation studies of hematopoietic progenitors (Schofield, 1978), niches are defined as microenvironments that anatomically house stem cells and functionally control their development in vivo.”
• The Ecological Niche: History and Recent Controversies (2015, unknown): “27 In cell biology, yet another niche concept has been used to explain the apparent immortality of certain stem cells 28 (Schofi eld 1978 : 13–15, 1983 : 277).”
• Mesenchymal stem cells: revisiting history, concepts, and assays. (2008, result): “As conceptualized by the stem cell niche hypothesis proposed by Schofield (1978), the notion that hematopoietic stem cells (HSCs) are regulated by their physical association with a discrete cellular microenvironment within BM was substantiated by the seminal observations of Dexter, Allen, and…”
• Dominant role of the niche in melanocyte stem-cell fate determination (2002, background): “gif" NDATA ITEM> ]> Stem cells—which have the capacity to self-renew and generate differentiated progeny—are thought to be maintained in a specific environment known as a nich”
• Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine (2009, background): “The stem cell niche concept was first proposed as a specialized micro-environment needed for cells to retain their ‘stemness’ (Schofield, 1978).”
• Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. (2010, methodology): “We now have congruent data from 2 inbred mouse strains demonstrating that: (1) osteoclast numbers and bone degradation increase only after cessation of G-CSF treatment and (2) that bisphosphonates (zoledronate or pamidronate15) synergize with G-CSF to increase CFC mobilization.”
• A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration (2009, unknown): “They are often characterized by their slowly cycling nature and their location within a niche, features thought to preserve their ability to self-renew and remain undifferentiated over the lifetime of the animal (Schofield, 1978).”
• Asymmetric and symmetric stem-cell divisions in development and cancer (2006, background): “A stem-cell niche is defined as a ‘microenvironment’ that promotes stem-cell maintenance (ref”
• Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “An important aspect of the stem cell concept is the proposal that there exists a “niche,” a special local microenvironment that is essential for the establishment and/or maintenance of stem cell function (Schofield 1978).”