Dominant role of the niche in melanocyte stem-cell fate determination

By E. Nishimura, S. Jordan, H. Oshima, H. Yoshida, M. Osawa, M. Moriyama, I. Jackson, Y. Barrandon, Y. Miyachi, S. Nishikawa. Nature, 2002

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A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “Lineage-committed melanocyte stem cells have also been reported in mouse hair follicles (46).”
Wound healing and skin regeneration. (2015, background): “In the normal skin, melanocyte stem cells (McSCs), responsible for hair pigmentation, are located in the hair follicle bulge and secondary hair germ niche together with epithelial stem cells (Nishimura et al. 2002).”
Signaling Pathways in Melanogenesis (2016, background): “Maintenance of the melanocyte population is dependent on the presence of MelSCs, a quiescent population that remains present in the bulge region of the hair follicle [84,85] and that expresses TYRP2 and TYRP1, but lacks TYR expression [86].”
Skin melanocytes: biology and development (2013, background): “After stimulation these cells migrate in the basal layer of the epidermis and differentiate into mature melanocytes [64, 78].”